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Tbio
ACTN1
Alpha-actinin-1

Protein Summary
Description
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000193403
  • ENSP00000193403
  • ENSG00000072110
  • ENST00000394419
  • ENSP00000377941
  • ENST00000438964
  • ENSP00000414272
  • ENST00000538545
  • ENSP00000439828

Symbol
  • BDPLT15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
1
viral protein
1
protein domain
0.99
hub protein
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.26   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.26   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
2
3
18.9
92.1
mean platelet volume
3
3
5
90.6
self reported educational attainment
1
1
1
54.7
platelet crit
1
1
1
20.5
Drugs used in diabetes use measurement
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
18.9
92.1
mean platelet volume
5
90.6
self reported educational attainment
1
54.7
platelet crit
1
20.5
Drugs used in diabetes use measurement
1
11.3
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Extracellular matrix organization
Hemostasis
Gene Ontology Terms (37)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
SynGO
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (267)
1 – 10 of 267
PDLIM1
Tbio
Novelty: 0.02703639
p_int: 0.996270775
p_ni: 0.003729225
Score: 0.861
Data Source: BioPlex,STRINGDB
ACTN4
Tbio
Novelty: 0.0040236
Score: 0.999
Data Source: STRINGDB
VCL
Tbio
Novelty: 0.00043107
Score: 0.999
Data Source: STRINGDB
ACTN2
Tbio
Novelty: 0.00615882
Score: 0.998
Data Source: STRINGDB
ZYX
Tbio
Novelty: 0.00375452
Score: 0.98
Data Source: STRINGDB
CTNNA1
Tbio
Novelty: 0.00925774
Score: 0.979
Data Source: STRINGDB
ACTN3
Tbio
Novelty: 0.00375035
Score: 0.978
Data Source: STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.974
Data Source: STRINGDB
ACTB
Tbio
Novelty: 0.00006048
Score: 0.97
Data Source: STRINGDB
ACTA1
Tbio
Novelty: 0.00111813
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  134.26

PubMed score by year
PubTator Score  706.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer