Protein Summary
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000193403
- ENSP00000193403
- ENSG00000072110
- ENST00000394419
- ENSP00000377941
- ENST00000438964
- ENSP00000414272
- ENST00000538545
- ENSP00000439828
- BDPLT15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
transcription factor perturbation | 1 | ||
viral protein | 1 | ||
protein domain | 0.99 | ||
hub protein | 0.98 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 134.26 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 436 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 134.26 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 436 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (6)
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1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 4 | 2 | 3 | 18.9 | 92.1 | ||||
mean platelet volume | 3 | 3 | 5 | 90.6 | |||||
self reported educational attainment | 1 | 1 | 1 | 54.7 | |||||
platelet crit | 1 | 1 | 1 | 20.5 | |||||
Drugs used in diabetes use measurement | 1 | 1 | 1 | 11.3 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 3 | 18.9 | 92.1 | ||||
mean platelet volume | 5 | 90.6 | |||||
self reported educational attainment | 1 | 54.7 | |||||
platelet crit | 1 | 20.5 | |||||
Drugs used in diabetes use measurement | 1 | 11.3 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | actinin alpha 1 | VGNC:6764 | 452993 | |||||
Macaque | actinin alpha 1 | 711994 | ||||||
Mouse | MGI:2137706 | 109711 | ||||||
Rat | RGD:70907 | 81634 | ||||||
Dog | actinin alpha 1 | VGNC:37548 | 480369 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | actinin alpha 1 | |||||
Macaque | actinin alpha 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | actinin alpha 1 | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (31)
Reactome (12)
KEGG (8)
PathwayCommons (6)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-extracellular matrix interactions | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-extracellular matrix interactions | ||||
Extracellular matrix organization | ||||
Hemostasis | ||||
Gene Ontology Terms (37)
Functions (9)
Components (18)
Processes (10)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | SynGO | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (267)
1 – 10 of 267
PDLIM1
Novelty: 0.02703639
p_int: 0.996270775
p_ni: 0.003729225
Score: 0.861
Data Source: BioPlex,STRINGDB
ACTN4
Novelty: 0.0040236
Score: 0.999
Data Source: STRINGDB
VCL
Novelty: 0.00043107
Score: 0.999
Data Source: STRINGDB
ACTN2
Novelty: 0.00615882
Score: 0.998
Data Source: STRINGDB
ZYX
Novelty: 0.00375452
Score: 0.98
Data Source: STRINGDB
CTNNA1
Novelty: 0.00925774
Score: 0.979
Data Source: STRINGDB
ACTN3
Novelty: 0.00375035
Score: 0.978
Data Source: STRINGDB
ITGB1
Novelty: 0.00055626
Score: 0.974
Data Source: STRINGDB
ACTB
Novelty: 0.00006048
Score: 0.97
Data Source: STRINGDB
ACTA1
Novelty: 0.00111813
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score 134.26
PubMed score by year
PubTator Score 706.46
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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