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Tbio
ACTN1
Alpha-actinin-1

Protein Summary
Description
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000193403
  • ENSP00000193403
  • ENSG00000072110
  • ENST00000394419
  • ENSP00000377941
  • ENST00000438964
  • ENSP00000414272
  • ENST00000538545
  • ENSP00000439828

Symbol
  • BDPLT15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
1
viral protein
1
protein domain
0.99
hub protein
0.98


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.55   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.55   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (267)
PDLIM1
Tbio
Novelty:  0.02703639
p_int:  0.996270775
p_ni:  0.003729225
Score:  0.861
Data Source:  BioPlex,STRINGDB
ACTN4
Tbio
Novelty:  0.0040236
Score:  0.999
Data Source:  STRINGDB
VCL
Tbio
Novelty:  0.00043107
Score:  0.999
Data Source:  STRINGDB
ACTN2
Tbio
Novelty:  0.00615882
Score:  0.998
Data Source:  STRINGDB
ZYX
Tbio
Novelty:  0.00375452
Score:  0.98
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.979
Data Source:  STRINGDB
ACTN3
Tbio
Novelty:  0.00375035
Score:  0.978
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.974
Data Source:  STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.97
Data Source:  STRINGDB
ACTA1
Tbio
Novelty:  0.00111813
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (31)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Extracellular matrix organization
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
SynGO
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
5
8
97.5
platelet count
6
6
8
18.9
96.9
3
3
0
1.1
81.7
fibrinogen measurement
4
4
4
75.5
eosinophil count
2
2
2
64.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
8
97.5
platelet count
8
18.9
96.9
0
1.1
81.7
fibrinogen measurement
4
75.5
eosinophil count
2
64.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actinin alpha 1
VGNC:6764
452993
Macaque
actinin alpha 1
711994
Mouse
MGI:2137706
109711
Rat
RGD:70907
81634
Dog
actinin alpha 1
VGNC:37548
480369
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actinin alpha 1
Macaque
actinin alpha 1
Mouse
Rat
Dog
actinin alpha 1
Publication Statistics
PubMed Score 140.55
PubMed score by year
PubTator Score 706.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title