Tbio ACTN1 Alpha-actinin-1

Protein Summary

Description

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P12814
• B3V8S3
• B4DHH3
• B7TY16
• Q1HE25
• Q9BTN1

Gene Name

• ACTN1

Ensembl ID

• ENST00000193403
• ENSP00000193403
• ENSG00000072110
• ENST00000394419
• ENSP00000377941
• ENST00000438964
• ENSP00000414272
• ENST00000538545
• ENSP00000439828

Symbol

• BDPLT15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
transcription factor perturbation	1
viral protein	1
protein domain	0.99
hub protein	0.98

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.55   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 436   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.55   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Protein-Protein Interactions (267)

Explore Interacting Targets

1 – 10 of 267

• See Interactions on String-DB

PDLIM1

Tbio

Novelty:  0.02703639

p_int:  0.996270775

p_ni:  0.003729225

Score:  0.861

Data Source:  BioPlex,STRINGDB

ACTN4

Tbio

Novelty:  0.0040236

Score:  0.999

Data Source:  STRINGDB

VCL

Tbio

Novelty:  0.00043107

Score:  0.999

Data Source:  STRINGDB

ACTN2

Tbio

Novelty:  0.00615882

Score:  0.998

Data Source:  STRINGDB

ZYX

Tbio

Novelty:  0.00375452

Score:  0.98

Data Source:  STRINGDB

CTNNA1

Tbio

Novelty:  0.00925774

Score:  0.979

Data Source:  STRINGDB

ACTN3

Tbio

Novelty:  0.00375035

Score:  0.978

Data Source:  STRINGDB

ITGB1

Tclin

Novelty:  0.00055626

Score:  0.974

Data Source:  STRINGDB

ACTB

Tbio

Novelty:  0.00006048

Score:  0.97

Data Source:  STRINGDB

ACTA1

Tbio

Novelty:  0.00111813

Score:  0.966

Data Source:  STRINGDB

Pathways (31)

Reactome (12)

KEGG (8)

PathwayCommons (6)

WikiPathways (5)

Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-extracellular matrix interactions	16 targets	R-HSA-446353
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-extracellular matrix interactions	16 targets	R-HSA-446353
Extracellular matrix organization	297 targets	R-HSA-1474244
Hemostasis	666 targets	R-HSA-109582

Gene Ontology Terms (37)

Functions (9)

Components (18)

Processes (10)

Find Similar Targets

Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Direct Assay (IDA)	UniProtKB
double-stranded RNA binding	Inferred from Direct Assay (IDA)	MGI
integrin binding	Inferred from Direct Assay (IDA)	UniProtKB
nuclear receptor transcription coactivator activity	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
structural constituent of postsynapse	Inferred from Direct Assay (IDA)	SynGO
vinculin binding	Inferred from Direct Assay (IDA)	UniProtKB
ion channel binding	Inferred from Physical Interaction (IPI)	UniProtKB
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

GWAS Traits (32)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 32

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	3	5	8		97.5
platelet count	EFO_0004309	6	6	8	18.9	96.9
multiple sclerosis	EFO_0003885	3	3	0	1.1	81.7
fibrinogen measurement	EFO_0004623	4	4	4		75.5
eosinophil count	EFO_0004842	2	2	2		64.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 32

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	8		97.5
platelet count	EFO_0004309	8	18.9	96.9
multiple sclerosis	EFO_0003885	0	1.1	81.7
fibrinogen measurement	EFO_0004623	4		75.5
eosinophil count	EFO_0004842	2		64.2

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Actin-binding
Alternative splicing
Calcium
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasm

GWAS Trait Find Similar Targets

No Header	No Header
albuminuria
apolipoprotein A 1 measurement
BMI-adjusted waist-hip ratio
celiac disease
diastolic blood pressure
Drugs used in diabetes use measurement
eosinophil count
feeling emotionally hurt measurement
fibrinogen measurement
hematocrit

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	actinin alpha 1	VGNC:6764	452993
Macaque	actinin alpha 1		711994
Mouse	actinin, alpha 1	MGI:2137706	109711
Rat	actinin, alpha 1	RGD:70907	81634
Dog	actinin alpha 1	VGNC:37548	480369

Species	Name	OMA	EggNOG	Inparanoid
Chimp	actinin alpha 1
Macaque	actinin alpha 1
Mouse	actinin, alpha 1
Rat	actinin, alpha 1
Dog	actinin alpha 1

Publication Statistics

PubMed Score 140.55

PubMed score by year

Reset Zoom

PubTator Score 706.46

PubTator score by year

Reset Zoom