Protein Summary
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000193403
- ENSP00000193403
- ENSG00000072110
- ENST00000394419
- ENSP00000377941
- ENST00000438964
- ENSP00000414272
- ENST00000538545
- ENSP00000439828
- BDPLT15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
transcription factor perturbation | 1 | ||
viral protein | 1 | ||
protein domain | 0.99 | ||
hub protein | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 140.55 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 436 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 140.55 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 436 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (267)
PDLIM1
Novelty: 0.02703639
p_int: 0.996270775
p_ni: 0.003729225
Score: 0.861
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (2)
Downstream (1)
1 – 2 of 2
Pathways (31)
Reactome (12)
KEGG (8)
PathwayCommons (6)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-extracellular matrix interactions | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-extracellular matrix interactions | ||||
Extracellular matrix organization | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (37)
Functions (9)
Components (18)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | SynGO | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 5 | 8 | 97.5 | |||||
platelet count | 6 | 6 | 8 | 18.9 | 96.9 | ||||
3 | 3 | 0 | 1.1 | 81.7 | |||||
fibrinogen measurement | 4 | 4 | 4 | 75.5 | |||||
eosinophil count | 2 | 2 | 2 | 64.2 | |||||
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 8 | 97.5 | |||||
platelet count | 8 | 18.9 | 96.9 | ||||
0 | 1.1 | 81.7 | |||||
fibrinogen measurement | 4 | 75.5 | |||||
eosinophil count | 2 | 64.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | actinin alpha 1 | VGNC:6764 | 452993 | |||||
Macaque | actinin alpha 1 | 711994 | ||||||
Mouse | MGI:2137706 | 109711 | ||||||
Rat | RGD:70907 | 81634 | ||||||
Dog | actinin alpha 1 | VGNC:37548 | 480369 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | actinin alpha 1 | |||||
Macaque | actinin alpha 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | actinin alpha 1 | |||||
Publication Statistics
PubMed Score 140.55
PubMed score by year
PubTator Score 706.46
PubTator score by year
Related Publications
Text Mined References (140)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
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