Protein Summary
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000193403
- ENSP00000193403
- ENSG00000072110
- ENST00000394419
- ENSP00000377941
- ENST00000438964
- ENSP00000414272
- ENST00000538545
- ENSP00000439828
- BDPLT15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
transcription factor perturbation | 1 | ||
viral protein | 1 | ||
protein domain | 0.99 | ||
hub protein | 0.98 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 134.26 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 436 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 134.26 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 436 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 4 | 2 | 3 | 18.9 | 92.1 | ||||
mean platelet volume | 3 | 3 | 5 | 90.6 | |||||
self reported educational attainment | 1 | 1 | 1 | 54.7 | |||||
platelet crit | 1 | 1 | 1 | 20.5 | |||||
Drugs used in diabetes use measurement | 1 | 1 | 1 | 11.3 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 3 | 18.9 | 92.1 | ||||
mean platelet volume | 5 | 90.6 | |||||
self reported educational attainment | 1 | 54.7 | |||||
platelet crit | 1 | 20.5 | |||||
Drugs used in diabetes use measurement | 1 | 11.3 | |||||
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (31)
Reactome (12)
KEGG (8)
PathwayCommons (6)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-extracellular matrix interactions | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-extracellular matrix interactions | ||||
Extracellular matrix organization | ||||
Hemostasis | ||||
Gene Ontology Terms (37)
Functions (9)
Components (18)
Processes (10)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | SynGO | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (267)
1 – 10 of 267
PDLIM1
Novelty: 0.02703639
p_int: 0.996270775
p_ni: 0.003729225
Score: 0.861
Data Source: BioPlex,STRINGDB
ACTN4
Novelty: 0.0040236
Score: 0.999
Data Source: STRINGDB
VCL
Novelty: 0.00043107
Score: 0.999
Data Source: STRINGDB
ACTN2
Novelty: 0.00615882
Score: 0.998
Data Source: STRINGDB
ZYX
Novelty: 0.00375452
Score: 0.98
Data Source: STRINGDB
CTNNA1
Novelty: 0.00925774
Score: 0.979
Data Source: STRINGDB
ACTN3
Novelty: 0.00375035
Score: 0.978
Data Source: STRINGDB
ITGB1
Novelty: 0.00055626
Score: 0.974
Data Source: STRINGDB
ACTB
Novelty: 0.00006048
Score: 0.97
Data Source: STRINGDB
ACTA1
Novelty: 0.00111813
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score 134.26
PubMed score by year
PubTator Score 706.46
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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