Tbio SKIL Ski-like protein

Protein Summary

Description

May have regulatory role in cell division or differentiation in response to extracellular signals. The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P12757
• A6NGT1
• B4DT50
• O00464
• P12756
• Q07501

Gene Name

• SKIL

Ensembl ID

• ENST00000259119
• ENSP00000259119
• ENSG00000136603
• ENST00000413427
• ENSP00000400193
• ENST00000426052
• ENSP00000406520
• ENST00000458537
• ENSP00000415243

Symbol

• SNO
• SNO
• SnoA
• SnoI
• SnoN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.96
transcription factor binding site profile	0.95
hub protein	0.9
transcription factor	0.87
molecular function	0.86

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.98   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 469   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.98   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 469   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
creatinine measurement	EFO_0004518	2	1	2		25.9
glomerular filtration rate	EFO_0005208	2	1	2		25.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
creatinine measurement	EFO_0004518	2		25.9
glomerular filtration rate	EFO_0005208	2		25.9

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Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	SKI like proto-oncogene	VGNC:14233	460844
Mouse	SKI-like	MGI:106203	20482
Rat	SKI-like proto-oncogene	RGD:621399	114208
Dog	SKI like proto-oncogene	VGNC:46199	488159
Horse	SKI like proto-oncogene	VGNC:23001	100057606

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SKI like proto-oncogene
Mouse	SKI-like
Rat	SKI-like proto-oncogene
Dog	SKI like proto-oncogene
Horse	SKI like proto-oncogene

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (20)

Reactome (8)

KEGG (1)

PathwayCommons (6)

WikiPathways (5)

Downregulation of SMAD2/3:SMAD4 transcriptional activity (R-HSA-2173795)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Downregulation of SMAD2/3:SMAD4 transcriptional activity	23 targets	R-HSA-2173795
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Downregulation of SMAD2/3:SMAD4 transcriptional activity	23 targets	R-HSA-2173795
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Signal Transduction	2704 targets	R-HSA-162582

Gene Ontology Terms (34)

Functions (8)

Components (6)

Processes (20)

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GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	UniProtKB
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
transcription corepressor activity	Inferred from Direct Assay (IDA)	UniProtKB
protein domain specific binding	Inferred from Physical Interaction (IPI)	UniProtKB
SMAD binding	Inferred from Physical Interaction (IPI)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB
chromatin binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (67)

Explore Interacting Targets

1 – 10 of 67

• See Interactions on String-DB

SMAD4

Tbio

Family: TF

Novelty: 0.00047069

p_int: 0.999999999

Score: 0.998

Data Source: BioPlex,Reactome,STRINGDB

SMAD2

Tbio

Family: TF

Novelty: 0.00040166

p_int: 0.999999934

p_ni: 5.6e-8

p_wrong: 1.1e-8

Score: 0.991

Data Source: BioPlex,Reactome,STRINGDB

SMAD3

Tbio

Family: TF

Novelty: 0.00048058

Score: 0.991

Data Source: Reactome,STRINGDB

SMURF2

Tbio

Family: Enzyme

Novelty: 0.00920984

Score: 0.983

Data Source: STRINGDB

RNF111

Tbio

Family: Enzyme

Novelty: 0.03059486

Score: 0.982

Data Source: STRINGDB

NCOR1

Tchem

Family: TF

Novelty: 0.0021926

Score: 0.958

Data Source: Reactome,STRINGDB

SIN3A

Tbio

Novelty: 0.00747207

Score: 0.946

Data Source: STRINGDB

HDAC1

Tclin

Family: Epigenetic

Novelty: 0.00065244

Score: 0.94

Data Source: STRINGDB

SKI

Tbio

Novelty: 0.02109924

Score: 0.939

Data Source: STRINGDB

EP300

Tchem

Family: Epigenetic

Novelty: 0.00055009

Score: 0.937

Data Source: STRINGDB

Publication Statistics

PubMed Score  150.98

PubMed score by year

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PubTator Score  79.63

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Coiled coil
Complete proteome
Isopeptide bond
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation

GWAS Trait Find Similar Targets

creatinine measurement
glomerular filtration rate

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging
neoplasm