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Tbio
SKIL
Ski-like protein

Protein Summary
Description
May have regulatory role in cell division or differentiation in response to extracellular signals. The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259119
  • ENSP00000259119
  • ENSG00000136603
  • ENST00000413427
  • ENSP00000400193
  • ENST00000426052
  • ENSP00000406520
  • ENST00000458537
  • ENSP00000415243

Symbol
  • SNO
  • SNO
  • SnoA
  • SnoI
  • SnoN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
transcription factor binding site profile
0.95
hub protein
0.9
transcription factor
0.87
molecular function
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.98   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 469   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.98   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 469   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
2
1
2
25.9
glomerular filtration rate
2
1
2
25.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
2
25.9
glomerular filtration rate
2
25.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SKI like proto-oncogene
VGNC:14233
460844
Mouse
MGI:106203
20482
Rat
RGD:621399
114208
Dog
SKI like proto-oncogene
VGNC:46199
488159
Horse
SKI like proto-oncogene
VGNC:23001
100057606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SKI like proto-oncogene
Mouse
Rat
Dog
SKI like proto-oncogene
Horse
SKI like proto-oncogene
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (R-HSA-2173795)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Signal Transduction
Gene Ontology Terms (34)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (67)
1 – 10 of 67
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
p_int: 0.999999999
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
p_int: 0.999999934
p_ni: 5.6e-8
p_wrong: 1.1e-8
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.991
Data Source: Reactome,STRINGDB
SMURF2
Tbio
Family: Enzyme
Novelty: 0.00920984
Score: 0.983
Data Source: STRINGDB
RNF111
Tbio
Family: Enzyme
Novelty: 0.03059486
Score: 0.982
Data Source: STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.958
Data Source: Reactome,STRINGDB
SIN3A
Tbio
Novelty: 0.00747207
Score: 0.946
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.94
Data Source: STRINGDB
SKI
Tbio
Novelty: 0.02109924
Score: 0.939
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  150.98

PubMed score by year
PubTator Score  79.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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