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Tbio
SKIL
Ski-like protein

Protein Summary
Description
May have regulatory role in cell division or differentiation in response to extracellular signals. The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259119
  • ENSP00000259119
  • ENSG00000136603
  • ENST00000413427
  • ENSP00000400193
  • ENST00000426052
  • ENSP00000406520
  • ENST00000458537
  • ENSP00000415243

Symbol
  • SNO
  • SNO
  • SnoA
  • SnoI
  • SnoN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
transcription factor binding site profile
0.95
hub protein
0.9
transcription factor
0.87
molecular function
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.26   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 469   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.26   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 469   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (R-HSA-2173795)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Signal Transduction
Gene Ontology Terms (34)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (67)
1 – 10 of 67
SMAD4
Tbio
Family: TF
Novelty: 0.00064135
p_int: 0.999999999
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00049143
p_int: 0.999999934
p_ni: 5.6e-8
p_wrong: 1.1e-8
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00058288
Score: 0.991
Data Source: Reactome,STRINGDB
SMURF2
Tbio
Family: Enzyme
Novelty: 0.01217466
Score: 0.983
Data Source: STRINGDB
RNF111
Tbio
Family: Enzyme
Novelty: 0.03941441
Score: 0.982
Data Source: STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.00288779
Score: 0.958
Data Source: Reactome,STRINGDB
SIN3A
Tbio
Novelty: 0.01059111
Score: 0.946
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00083441
Score: 0.94
Data Source: STRINGDB
SKI
Tbio
Novelty: 0.01444515
Score: 0.939
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00060382
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  187.26

PubMed score by year
PubTator Score  79.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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