Protein Summary
May have regulatory role in cell division or differentiation in response to extracellular signals. The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000259119
- ENSP00000259119
- ENSG00000136603
- ENST00000413427
- ENSP00000400193
- ENST00000426052
- ENSP00000406520
- ENST00000458537
- ENSP00000415243
- SNO
- SNO
- SnoA
- SnoI
- SnoN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.96 | ||
transcription factor binding site profile | 0.95 | ||
hub protein | 0.9 | ||
transcription factor | 0.87 | ||
molecular function | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 154.19 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 469 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 154.19 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 469 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (67)
Nearest Tclin Targets
Pathways (20)
Reactome (8)
KEGG (1)
PathwayCommons (6)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Downregulation of SMAD2/3:SMAD4 transcriptional activity | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Downregulation of SMAD2/3:SMAD4 transcriptional activity | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (34)
Functions (8)
Components (6)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
6 | 3 | 0 | 1.2 | 91.6 | |||||
glomerular filtration rate | 3 | 2 | 3 | 31.3 | |||||
creatinine measurement | 2 | 1 | 2 | 17.8 | |||||
urinary albumin to creatinine ratio | 3 | 1 | 3 | 14.1 | |||||
albuminuria | 1 | 1 | 1 | 12.6 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 91.6 | |||||
glomerular filtration rate | 3 | 31.3 | |||||
creatinine measurement | 2 | 17.8 | |||||
urinary albumin to creatinine ratio | 3 | 14.1 | |||||
albuminuria | 1 | 12.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SKI like proto-oncogene | VGNC:14233 | 460844 | |||||
Mouse | MGI:106203 | 20482 | ||||||
Rat | RGD:621399 | 114208 | ||||||
Dog | SKI like proto-oncogene | VGNC:46199 | 488159 | |||||
Horse | SKI like proto-oncogene | VGNC:23001 | 100057606 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SKI like proto-oncogene | |||||
Mouse | ||||||
Rat | ||||||
Dog | SKI like proto-oncogene | |||||
Horse | SKI like proto-oncogene | |||||
Publication Statistics
PubMed Score 154.19
PubMed score by year
PubTator Score 79.63
PubTator score by year
Related Publications
Text Mined References (78)
GeneRif Annotations (49)
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0 of 0
PMID | Year | Title |
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