Tbio SKIL Ski-like protein

Protein Summary

Description

May have regulatory role in cell division or differentiation in response to extracellular signals. The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P12757
• A6NGT1
• B4DT50
• O00464
• P12756
• Q07501

Gene Name

• SKIL

Ensembl ID

• ENST00000259119
• ENSP00000259119
• ENSG00000136603
• ENST00000413427
• ENSP00000400193
• ENST00000426052
• ENSP00000406520
• ENST00000458537
• ENSP00000415243

Symbol

• SNO
• SNO
• SnoA
• SnoI
• SnoN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.96
transcription factor binding site profile	0.95
hub protein	0.9
transcription factor	0.87
molecular function	0.86

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.26   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 469   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.26   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 469   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (20)

Reactome (8)

KEGG (1)

PathwayCommons (6)

WikiPathways (5)

Downregulation of SMAD2/3:SMAD4 transcriptional activity (R-HSA-2173795)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Downregulation of SMAD2/3:SMAD4 transcriptional activity	23 targets	R-HSA-2173795
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Downregulation of SMAD2/3:SMAD4 transcriptional activity	23 targets	R-HSA-2173795
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Signal Transduction	2704 targets	R-HSA-162582

Gene Ontology Terms (34)

Functions (8)

Components (6)

Processes (20)

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1 – 8 of 8

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	UniProtKB
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
transcription corepressor activity	Inferred from Direct Assay (IDA)	UniProtKB
protein domain specific binding	Inferred from Physical Interaction (IPI)	UniProtKB
SMAD binding	Inferred from Physical Interaction (IPI)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB
chromatin binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (67)

Explore Interacting Targets

1 – 10 of 67

• See Interactions on String-DB

SMAD4

Tbio

Family: TF

Novelty: 0.00064135

p_int: 0.999999999

Score: 0.998

Data Source: BioPlex,Reactome,STRINGDB

SMAD2

Tbio

Family: TF

Novelty: 0.00049143

p_int: 0.999999934

p_ni: 5.6e-8

p_wrong: 1.1e-8

Score: 0.991

Data Source: BioPlex,Reactome,STRINGDB

SMAD3

Tbio

Family: TF

Novelty: 0.00058288

Score: 0.991

Data Source: Reactome,STRINGDB

SMURF2

Tbio

Family: Enzyme

Novelty: 0.01217466

Score: 0.983

Data Source: STRINGDB

RNF111

Tbio

Family: Enzyme

Novelty: 0.03941441

Score: 0.982

Data Source: STRINGDB

NCOR1

Tchem

Family: TF

Novelty: 0.00288779

Score: 0.958

Data Source: Reactome,STRINGDB

SIN3A

Tbio

Novelty: 0.01059111

Score: 0.946

Data Source: STRINGDB

HDAC1

Tclin

Family: Epigenetic

Novelty: 0.00083441

Score: 0.94

Data Source: STRINGDB

SKI

Tbio

Novelty: 0.01444515

Score: 0.939

Data Source: STRINGDB

EP300

Tchem

Family: Epigenetic

Novelty: 0.00060382

Score: 0.937

Data Source: STRINGDB

Publication Statistics

PubMed Score  187.26

PubMed score by year

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PubTator Score  79.63

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Coiled coil
Complete proteome
Isopeptide bond
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation

GWAS Trait Find Similar Targets

albuminuria
creatinine measurement
glomerular filtration rate
Microalbuminuria
prostate carcinoma
urinary albumin to creatinine ratio

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging
neoplasm