Protein Summary
May have regulatory role in cell division or differentiation in response to extracellular signals. The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000259119
- ENSP00000259119
- ENSG00000136603
- ENST00000413427
- ENSP00000400193
- ENST00000426052
- ENSP00000406520
- ENST00000458537
- ENSP00000415243
- SNO
- SNO
- SnoA
- SnoI
- SnoN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.96 | ||
transcription factor binding site profile | 0.95 | ||
hub protein | 0.9 | ||
transcription factor | 0.87 | ||
molecular function | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 177.6 (req: < 5)
Gene RIFs: 57 (req: <= 3)
Antibodies: 469 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 177.6 (req: >= 5)
Gene RIFs: 57 (req: > 3)
Antibodies: 469 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0