Protein Summary
May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
- ENST00000378536
- ENSP00000367797
- ENSG00000157933
- SGS
- SKV
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 0.9 | ||
disease perturbation | 0.87 | ||
protein domain | 0.85 | ||
transcription factor binding site profile | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.13 (req: < 5)
Gene RIFs: 65 (req: <= 3)
Antibodies: 174 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.13 (req: >= 5)
Gene RIFs: 65 (req: > 3)
Antibodies: 174 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 45
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (53)
SMAD4
Family: TF
Novelty: 0.00047069
p_int: 0.999999955
p_ni: 2.7e-8
p_wrong: 1.8e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SMAD2
Family: TF
Novelty: 0.00040166
p_int: 0.99999954
p_ni: 4.59e-7
p_wrong: 1e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
RALBP1
Novelty: 0.01525176
p_int: 0.999993465
p_ni: 2.6e-8
p_wrong: 0.000006509
Score: 0.189
Data Source: BioPlex,STRINGDB
LTBR
Novelty: 0.003823
p_int: 0.996888058
p_ni: 0.00000218
p_wrong: 0.003109762
Score: 0.181
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (60)
Reactome (9)
PathwayCommons (8)
WikiPathways (43)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Downregulation of SMAD2/3:SMAD4 transcriptional activity | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Downregulation of SMAD2/3:SMAD4 transcriptional activity | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (54)
Functions (9)
Components (9)
Processes (36)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence Model (ISM) | NTNU_SB | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 5 | 4 | 5 | 87.7 | |||||
alkaline phosphatase measurement | 2 | 2 | 1 | 8.1 | 85.6 | ||||
platelet count | 2 | 2 | 2 | 83.7 | |||||
platelet crit | 2 | 2 | 2 | 80.4 | |||||
serum alanine aminotransferase measurement | 2 | 2 | 1 | 6 | 76.2 | ||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 5 | 87.7 | |||||
alkaline phosphatase measurement | 1 | 8.1 | 85.6 | ||||
platelet count | 2 | 83.7 | |||||
platelet crit | 2 | 80.4 | |||||
serum alanine aminotransferase measurement | 1 | 6 | 76.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SKI proto-oncogene | VGNC:11006 | 457216 | |||||
Macaque | SKI proto-oncogene | 697890 | ||||||
Mouse | MGI:98310 | 20481 | ||||||
Dog | SKI proto-oncogene | VGNC:46198 | 489610 | |||||
Horse | SKI proto-oncogene | 100033833 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SKI proto-oncogene | |||||
Macaque | SKI proto-oncogene | |||||
Mouse | ||||||
Dog | SKI proto-oncogene | |||||
Horse | SKI proto-oncogene | |||||
Publication Statistics
PubMed Score 42.13
PubMed score by year
PubTator Score 1191.99
PubTator score by year
Related Publications
Text Mined References (104)
GeneRif Annotations (65)
Items per page:
0 of 0
PMID | Year | Title |
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