Tbio SKI Ski oncogene

Protein Summary

Description

May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P12755
• Q5SYT7

Gene Name

• SKI

Ensembl ID

• ENST00000378536
• ENSP00000367797
• ENSG00000157933

Symbol

• SGS
• SKV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.9
disease perturbation	0.87
protein domain	0.85
transcription factor binding site profile	0.81

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.91   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.91   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		82.2
platelet count	EFO_0004309	1	1	1		50.6
platelet crit	EFO_0007985	1	1	1		46.5
physical activity measurement	EFO_0008002	1	1	1		28.7
systolic blood pressure	EFO_0006335	1	1	1		20.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	1		82.2
platelet count	EFO_0004309	1		50.6
platelet crit	EFO_0007985	1		46.5
physical activity measurement	EFO_0008002	1		28.7
systolic blood pressure	EFO_0006335	1		20.2

Reset Zoom  Beta Count   Odds Ratio

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	SKI proto-oncogene	VGNC:11006	457216
Macaque	SKI proto-oncogene		697890
Mouse	ski sarcoma viral oncogene homolog (avian)	MGI:98310	20481
Dog	SKI proto-oncogene	VGNC:46198	489610
Horse	SKI proto-oncogene		100033833

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SKI proto-oncogene
Macaque	SKI proto-oncogene
Mouse	ski sarcoma viral oncogene homolog (avian)
Dog	SKI proto-oncogene
Horse	SKI proto-oncogene

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12755-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (60)

Reactome (9)

PathwayCommons (8)

WikiPathways (43)

Downregulation of SMAD2/3:SMAD4 transcriptional activity (R-HSA-2173795)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Downregulation of SMAD2/3:SMAD4 transcriptional activity	23 targets	R-HSA-2173795
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Downregulation of SMAD2/3:SMAD4 transcriptional activity	23 targets	R-HSA-2173795
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Signal Transduction	2704 targets	R-HSA-162582

Gene Ontology Terms (54)

Functions (9)

Components (9)

Processes (36)

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1 – 9 of 9

GO Term	Evidence	Assigned by
transcription corepressor activity	Inferred from Direct Assay (IDA)	UniProtKB
zinc ion binding	Inferred from Direct Assay (IDA)	UniProtKB
protein domain specific binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB
repressing transcription factor binding	Inferred from Physical Interaction (IPI)	UniProtKB
SMAD binding	Inferred from Physical Interaction (IPI)	UniProtKB
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	UniProtKB
histone deacetylase inhibitor activity	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Model (ISM)	NTNU_SB

Protein-Protein Interactions (53)

Explore Interacting Targets

1 – 10 of 53

• See Interactions on String-DB

SMAD4

Tbio

Family: TF

Novelty: 0.00047069

p_int: 0.999999955

p_ni: 2.7e-8

p_wrong: 1.8e-8

Score: 0.998

Data Source: BioPlex,Reactome,STRINGDB

SMAD2

Tbio

Family: TF

Novelty: 0.00040166

p_int: 0.99999954

p_ni: 4.59e-7

p_wrong: 1e-9

Score: 0.987

Data Source: BioPlex,Reactome,STRINGDB

RALBP1

Tbio

Novelty: 0.01525176

p_int: 0.999993465

p_ni: 2.6e-8

p_wrong: 0.000006509

Score: 0.189

Data Source: BioPlex,STRINGDB

LTBR

Tbio

Novelty: 0.003823

p_int: 0.996888058

p_ni: 0.00000218

p_wrong: 0.003109762

Score: 0.181

Data Source: BioPlex,STRINGDB

SMAD3

Tbio

Family: TF

Novelty: 0.00048058

Score: 0.986

Data Source: Reactome,STRINGDB

SMAD5

Tbio

Family: TF

Novelty: 0.00405952

Score: 0.983

Data Source: Reactome,STRINGDB

SMAD1

Tbio

Family: TF

Novelty: 0.02348173

Score: 0.983

Data Source: Reactome,STRINGDB

SMAD9

Tbio

Family: TF

Novelty: 0.00285887

Score: 0.972

Data Source: Reactome,STRINGDB

NCOR1

Tchem

Family: TF

Novelty: 0.0021926

Score: 0.968

Data Source: Reactome,STRINGDB

SMURF2

Tbio

Family: Enzyme

Novelty: 0.00920984

Score: 0.962

Data Source: STRINGDB

Publication Statistics

PubMed Score  41.91

PubMed score by year

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PubTator Score  1191.99

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Coiled coil
Complete proteome
Craniosynostosis
Disease mutation
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
Repeat

GWAS Trait Find Similar Targets

coronary artery disease
low density lipoprotein cholesterol measurement
physical activity measurement
platelet count
platelet crit
systolic blood pressure

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
embryo phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
limbs/digits/tail phenotype
mortality/aging
muscle phenotype
neoplasm