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Tbio
SKI
Ski oncogene

Protein Summary
Description
May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378536
  • ENSP00000367797
  • ENSG00000157933

Symbol
  • SGS
  • SKV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.9
disease perturbation
0.87
protein domain
0.85
transcription factor binding site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.91   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.91   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
82.2
platelet count
1
1
1
50.6
platelet crit
1
1
1
46.5
physical activity measurement
1
1
1
28.7
systolic blood pressure
1
1
1
20.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
82.2
platelet count
1
50.6
platelet crit
1
46.5
physical activity measurement
1
28.7
systolic blood pressure
1
20.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SKI proto-oncogene
VGNC:11006
457216
Macaque
SKI proto-oncogene
697890
Mouse
MGI:98310
20481
Dog
SKI proto-oncogene
VGNC:46198
489610
Horse
SKI proto-oncogene
100033833
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SKI proto-oncogene
Macaque
SKI proto-oncogene
Mouse
Dog
SKI proto-oncogene
Horse
SKI proto-oncogene
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (60)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (R-HSA-2173795)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Signal Transduction
Gene Ontology Terms (54)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Model (ISM)
NTNU_SB
Protein-Protein Interactions (53)
1 – 10 of 53
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
p_int: 0.999999955
p_ni: 2.7e-8
p_wrong: 1.8e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
p_int: 0.99999954
p_ni: 4.59e-7
p_wrong: 1e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
RALBP1
Tbio
Novelty: 0.01525176
p_int: 0.999993465
p_ni: 2.6e-8
p_wrong: 0.000006509
Score: 0.189
Data Source: BioPlex,STRINGDB
LTBR
Tbio
Novelty: 0.003823
p_int: 0.996888058
p_ni: 0.00000218
p_wrong: 0.003109762
Score: 0.181
Data Source: BioPlex,STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.986
Data Source: Reactome,STRINGDB
SMAD5
Tbio
Family: TF
Novelty: 0.00405952
Score: 0.983
Data Source: Reactome,STRINGDB
SMAD1
Tbio
Family: TF
Novelty: 0.02348173
Score: 0.983
Data Source: Reactome,STRINGDB
SMAD9
Tbio
Family: TF
Novelty: 0.00285887
Score: 0.972
Data Source: Reactome,STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.968
Data Source: Reactome,STRINGDB
SMURF2
Tbio
Family: Enzyme
Novelty: 0.00920984
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.91

PubMed score by year
PubTator Score  1191.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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