Tbio RNASE3 Eosinophil cationic protein

Protein Summary

Description

Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P12724
• Q4VBC1
• Q8WTP7
• Q8WZ62
• Q9GZN9
• ECP

Gene Name

• RNASE3

Ensembl ID

• ENST00000304639
• ENSP00000302324
• ENSG00000169397

Symbol

• ECP
• RNS3
• ECP
• RAF1
• RNS3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.81
phenotype	0.57
tissue	0.54
disease	0.52
chemical	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1681.28   (req: < 5)

Gene RIFs: 100   (req: <= 3)

Antibodies: 279   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1681.28   (req: >= 5)

Gene RIFs: 100   (req: > 3)

Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0