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Tchem
BMP4
Bone morphogenetic protein 4

Protein Summary
Description
Induces cartilage and bone formation. Also acts in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245451
  • ENSP00000245451
  • ENSG00000125378
  • ENST00000417573
  • ENSP00000394165
  • ENST00000558984
  • ENSP00000454134
  • ENST00000559087
  • ENSP00000453485

Symbol
  • BMP2B
  • DVR4
  • ZYME
  • BMP2B
  • OFC11
  • BMP2B1
  • MCOPS6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
PubMedID
1
gene perturbation
0.97
cell type or tissue
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2216.76   (req: < 5)
Gene RIFs: 306   (req: <= 3)
Antibodies: 767   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2216.76   (req: >= 5)
Gene RIFs: 306   (req: > 3)
Antibodies: 767   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 166
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
6
12
98.4
refractive error measurement
2
2
1
8.6
95.4
2
1
0
1.1
95.3
1
1
0
1.1
79
tooth eruption
1
1
1
72.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
12
98.4
refractive error measurement
1
8.6
95.4
0
1.1
95.3
0
1.1
79
tooth eruption
1
72.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 4
VGNC:3472
107968170
Macaque
bone morphogenetic protein 4
694618
Mouse
MGI:88180
12159
Rat
RGD:2213
25296
Dog
bone morphogenetic protein 4
VGNC:38480
490695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 4
Macaque
bone morphogenetic protein 4
Mouse
Rat
Dog
bone morphogenetic protein 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P12644-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (83)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Metabolism of proteins
Reactome
Molecules associated with elastic fibres
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Metabolism of proteins
Molecules associated with elastic fibres
Post-translational protein modification
Gene Ontology Terms (169)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (557)
1 – 10 of 557
DCAF16
Tdark
Novelty: 0.35666992
p_int: 0.999778343
p_ni: 0.000214832
p_wrong: 0.000006825
Score: 0.158
Data Source: BioPlex,STRINGDB
SLC22A23
Tbio
Family: Transporter
Novelty: 0.23405744
p_int: 0.999521467
p_ni: 0.000458655
p_wrong: 0.000019878
Score: 0.188
Data Source: BioPlex,STRINGDB
TWSG1
Tbio
Novelty: 0.00255544
p_int: 0.997020278
p_ni: 0.002955861
p_wrong: 0.000023861
Score: 0.894
Data Source: BioPlex,STRINGDB
UBE2O
Tbio
Novelty: 0.07084123
p_int: 0.949168643
p_ni: 0.050831357
Score: 0.161
Data Source: BioPlex,STRINGDB
PDP1
Tbio
Family: Enzyme
Novelty: 0.00442352
p_int: 0.934183698
p_ni: 0.065816302
Score: 0.204
Data Source: BioPlex,STRINGDB
SUFU
Tbio
Novelty: 0.00475249
p_int: 0.815304419
p_ni: 0.184695476
p_wrong: 1.05e-7
Score: 0.343
Data Source: BioPlex,STRINGDB
PROS1
Tbio
Novelty: 0.00275184
p_int: 0.768656534
p_ni: 0.231343466
Score: 0.272
Data Source: BioPlex,STRINGDB
CALR
Tbio
Novelty: 0.0004479
p_int: 0.758634768
p_ni: 0.241365232
Score: 0.373
Data Source: BioPlex,STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
Score: 0.998
Data Source: STRINGDB
BMPR1B
Tchem
Family: Kinase
Novelty: 0.00698763
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  2216.76

PubMed score by year
PubTator Score  875.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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