Tbio BMP2 Bone morphogenetic protein 2

Protein Summary

Description

Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P12643
• BMP-2

Gene Name

• BMP2

Ensembl ID

• ENST00000378827
• ENSP00000368104
• ENSG00000125845

Symbol

• BMP2A
• BDA2
• BMP2A
• SSFSC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
gene perturbation	1
PubMedID	0.94
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Bone Morphogenetic Protein 2

DTO Classes

Protein / Signaling / Growth Factor / Bone Morphogenetic Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7157.17   (req: < 5)

Gene RIFs: 607   (req: <= 3)

Antibodies: 887   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7157.17   (req: >= 5)

Gene RIFs: 607   (req: > 3)

Antibodies: 887   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 98

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0