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Tbio
BMP2
Bone morphogenetic protein 2

Protein Summary
Description
Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378827
  • ENSP00000368104
  • ENSG00000125845

Symbol
  • BMP2A
  • BDA2
  • BMP2A
  • SSFSC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
gene perturbation
1
PubMedID
0.94
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6342.46   (req: < 5)
Gene RIFs: 498   (req: <= 3)
Antibodies: 887   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6342.46   (req: >= 5)
Gene RIFs: 498   (req: > 3)
Antibodies: 887   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 98
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
6
8
96.1
refractive error measurement
2
2
1
5.9
75.9
1
1
0
1.1
9.2
1
1
0
1.1
9.2
Abnormality of refraction
1
1
1
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
8
96.1
refractive error measurement
1
5.9
75.9
0
1.1
9.2
0
1.1
9.2
Abnormality of refraction
1
4.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 2
VGNC:6052
458090
Macaque
bone morphogenetic protein 2
718330
Mouse
MGI:88177
12156
Rat
RGD:2211
29373
Dog
bone morphogenetic protein 2
VGNC:38478
477162
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bone morphogenetic protein 2
Macaque
bone morphogenetic protein 2
Mouse
Rat
Dog
bone morphogenetic protein 2
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12643-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (38)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Gene expression (Transcription)
Generic Transcription Pathway
Molecules associated with elastic fibres
Gene Ontology Terms (103)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (362)
1 – 10 of 362
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
Score: 0.999
Data Source: Reactome,STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
Score: 0.999
Data Source: Reactome,STRINGDB
CHRD
Tbio
Novelty: 0.00347659
Score: 0.998
Data Source: STRINGDB
RGMB
Tbio
Novelty: 0.05317349
Score: 0.998
Data Source: STRINGDB
RGMA
Tbio
Novelty: 0.00549021
Score: 0.997
Data Source: STRINGDB
ACVR2A
Tchem
Family: Kinase
Novelty: 0.0063932
Score: 0.996
Data Source: Reactome,STRINGDB
NOG
Tbio
Novelty: 0.0010373
Score: 0.995
Data Source: STRINGDB
HJV
Tbio
Novelty: 0.00495995
Score: 0.995
Data Source: STRINGDB
BMPR1B
Tchem
Family: Kinase
Novelty: 0.00698763
Score: 0.995
Data Source: Reactome,STRINGDB
BMPR2
Tchem
Family: Kinase
Novelty: 0.00155912
Score: 0.993
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  6342.46

PubMed score by year
PubTator Score  3017.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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