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Tbio
ANXA3
Annexin A3

Protein Summary
Description
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264908
  • ENSP00000264908
  • ENSG00000138772

Symbol
  • ANX3
  • ANX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.99
transcription factor perturbation
0.98
kinase perturbation
0.97
disease perturbation
0.96


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.64   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 536   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.64   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 536   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.999999887
p_ni:  1.13e-7
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.999907761
p_ni:  0.000083375
p_wrong:  0.000008864
Data Source:  BioPlex
PATE2
Tdark
Novelty:  0.33130253
p_int:  0.998751388
p_ni:  0.001239652
p_wrong:  0.00000896
Data Source:  BioPlex
SNAP23
Tbio
Novelty:  0.0065371
Score:  0.833
Data Source:  STRINGDB
ANXA11
Tbio
Novelty:  0.00925429
Score:  0.824
Data Source:  STRINGDB
STX4
Tbio
Novelty:  0.00831588
Score:  0.823
Data Source:  STRINGDB
STXBP2
Tbio
Novelty:  0.01896992
Score:  0.804
Data Source:  STRINGDB
DYSF
Tbio
Novelty:  0.00248634
Score:  0.738
Data Source:  STRINGDB
CD63
Tchem
Novelty:  0.00072515
Score:  0.663
Data Source:  STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.651
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Prostaglandin Synthesis and Regulation
WikiPathways
Prostaglandin Synthesis and Regulation
WikiPathways
HIF1A and PPARG regulation of glycolysis
WikiPathways
Sterol Regulatory Element-Binding Proteins (SREBP) signalling
WikiPathways
Transcription factor regulation in adipogenesis
Name
Explore in Pharos
Explore in Source
Prostaglandin Synthesis and Regulation
Prostaglandin Synthesis and Regulation
HIF1A and PPARG regulation of glycolysis
Sterol Regulatory Element-Binding Proteins (SREBP) signalling
Transcription factor regulation in adipogenesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
2
2
84.7
mean platelet volume
2
1
2
71.5
monocyte count
1
1
1
68.8
FEV/FEC ratio
1
1
1
66.8
creatine kinase measurement
1
1
1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
84.7
mean platelet volume
2
71.5
monocyte count
1
68.8
FEV/FEC ratio
1
66.8
creatine kinase measurement
1
56.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
annexin A3
VGNC:562
737760
Macaque
annexin A3
697239
Mouse
MGI:1201378
11745
Rat
RGD:2119
25291
Dog
annexin A3
VGNC:37940
478447
Species
Name
OMA
EggNOG
Inparanoid
Chimp
annexin A3
Macaque
annexin A3
Mouse
Rat
Dog
annexin A3
Publication Statistics
PubMed Score 173.64
PubMed score by year
PubTator Score 104.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title