FCGR2A
Low affinity immunoglobulin gamma Fc region receptor II-a
Protein Summary
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
- ENST00000271450
- ENSP00000271450
- ENSG00000143226
- ENST00000367972
- ENSP00000356949
- CD32
- FCG2
- FCGR2A1
- IGFR2
- CD32
- FCG2
- FcGR
- CD32A
- CDw32
- FCGR2
- IGFR2
- FCGR2A1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.86 | ||
gene perturbation | 0.84 | ||
drug | 0.81 | ||
phenotype | 0.79 | ||
kinase | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1267.01 (req: < 5)
Gene RIFs: 349 (req: <= 3)
Antibodies: 1230 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1267.01 (req: >= 5)
Gene RIFs: 349 (req: > 3)
Antibodies: 1230 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0