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Tbio
FCGR2A
Low affinity immunoglobulin gamma Fc region receptor II-a

Protein Classes
Protein Summary
Description
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271450
  • ENSP00000271450
  • ENSG00000143226
  • ENST00000367972
  • ENSP00000356949

Symbol
  • CD32
  • FCG2
  • FCGR2A1
  • IGFR2
  • CD32
  • FCG2
  • FcGR
  • CD32A
  • CDw32
  • FCGR2
  • IGFR2
  • FCGR2A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.86
gene perturbation
0.84
drug
0.81
phenotype
0.79
kinase
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1117.21   (req: < 5)
Gene RIFs: 302   (req: <= 3)
Antibodies: 1230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1117.21   (req: >= 5)
Gene RIFs: 302   (req: > 3)
Antibodies: 1230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
0
1.2
93.1
2
1
0
1.1
84.7
5
3
0
1.2
83.8
1
1
0
1.3
74.1
total cholesterol measurement
1
1
1
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
93.1
0
1.1
84.7
0
1.2
83.8
0
1.3
74.1
total cholesterol measurement
1
71.1
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (37)
FCGR activation (R-HSA-2029481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FCGR activation
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
FCGR activation
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (296)
1 – 10 of 296
APEX1
Tchem
Family: Enzyme
Novelty: 0.00037532
p_int: 0.999590465
p_ni: 0.000409535
Score: 0.404
Data Source: BioPlex,STRINGDB
FCGR2C
Tdark
p_int: 0.997858099
p_ni: 1e-9
p_wrong: 0.0021419
Data Source: BioPlex
FCGR2B
Tbio
Novelty: 0.00098166
p_int: 0.992167965
p_ni: 2e-9
p_wrong: 0.007832033
Score: 0.656
Data Source: BioPlex,STRINGDB
PRTFDC1
Tbio
Family: Enzyme
Novelty: 0.13607881
p_int: 0.985019062
p_ni: 0.004077268
p_wrong: 0.01090367
Score: 0.163
Data Source: BioPlex,STRINGDB
PLPBP
Tbio
Family: Enzyme
Novelty: 0.04352366
p_int: 0.98130283
p_ni: 0.016356483
p_wrong: 0.002340687
Score: 0.187
Data Source: BioPlex,STRINGDB
PLS1
Tbio
Novelty: 0.00538817
p_int: 0.971298097
p_ni: 0.028701903
Score: 0.151
Data Source: BioPlex,STRINGDB
FAHD2A
Tdark
Family: Enzyme
Novelty: 0.68981789
p_int: 0.960913099
p_ni: 0.039079559
p_wrong: 0.000007342
Score: 0.187
Data Source: BioPlex,STRINGDB
BLVRB
Tbio
Family: Enzyme
Novelty: 0.00705559
p_int: 0.957838896
p_ni: 0.008613189
p_wrong: 0.033547915
Score: 0.189
Data Source: BioPlex,STRINGDB
PPP3R1
Tbio
Novelty: 0.00263264
p_int: 0.95501147
p_ni: 0.044988077
p_wrong: 4.53e-7
Score: 0.178
Data Source: BioPlex,STRINGDB
TES
Tbio
Novelty: 0.00052221
p_int: 0.907140287
p_ni: 0.092855564
p_wrong: 0.000004149
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1117.21

PubMed score by year
PubTator Score  563.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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