Tclin FCGR1A High affinity immunoglobulin gamma Fc receptor I

Protein Summary

Description

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P12314
• P12315
• Q5QNW7
• Q92495
• Q92663
• IgG Fc receptor I

Gene Name

• FCGR1A

Ensembl ID

• ENST00000369168
• ENSP00000358165
• ENSG00000150337

Symbol

• FCG1
• FCGR1
• IGFR1
• CD64
• FCRI
• CD64A
• IGFR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
cellular component	0.88
drug	0.85
biological term	0.79
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / High Affinity Immunoglobulin Gamma Fc Receptor I

DTO Classes

Protein / Cell Adhesion / High Affinity Immunoglobulin Gamma Fc Receptor I

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1375.9   (req: < 5)

Gene RIFs: 107   (req: <= 3)

Antibodies: 1089   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1375.9   (req: >= 5)

Gene RIFs: 107   (req: > 3)

Antibodies: 1089   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

belantamab mafodotin

FCGR1ATclin

BINDING AGENT pKd : 9

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

CHEMBL2377172

FCGR1ATclin

pIC50 : 7

Protein-Protein Interactions (382)

Explore Interacting Targets

1 – 10 of 382

• See Interactions on String-DB

ITIH2

Tbio

Novelty:  0.04886358

p_int:  0.99916906

p_ni:  0.000810464

p_wrong:  0.000020476

Score:  0.162

Data Source:  BioPlex,STRINGDB

HBA1

Tclin

Novelty:  0.00094113

p_int:  0.995277328

p_ni:  0.004722661

p_wrong:  1.2e-8

Data Source:  BioPlex

PCDH17

Tbio

Novelty:  0.03341603

p_int:  0.991269012

p_ni:  0.000388273

p_wrong:  0.008342715

Score:  0.823

Data Source:  BioPlex,STRINGDB

PCDH12

Tbio

Novelty:  0.06268895

p_int:  0.989055834

p_ni:  0.000089016

p_wrong:  0.01085515

Score:  0.57

Data Source:  BioPlex,STRINGDB

FREM2

Tbio

Novelty:  0.03382033

p_int:  0.965645975

p_ni:  0.034354025

Score:  0.183

Data Source:  BioPlex,STRINGDB

PCDH7

Tbio

Novelty:  0.04017185

p_int:  0.96363898

p_ni:  0.03636102

Score:  0.795

Data Source:  BioPlex,STRINGDB

CDC42BPA

Tchem

Family:  Kinase

Novelty:  0.02575412

p_int:  0.849254386

p_ni:  0.150745614

Score:  0.195

Data Source:  BioPlex,STRINGDB

ULBP3

Tbio

Novelty:  0.0320239

p_int:  0.830825743

p_ni:  0.168853352

p_wrong:  0.000320905

Score:  0.166

Data Source:  BioPlex,STRINGDB

ACAD8

Tbio

Family:  Enzyme

Novelty:  0.05735881

p_int:  0.819087734

p_ni:  0.180912266

Score:  0.189

Data Source:  BioPlex,STRINGDB

FRAS1

Tbio

Novelty:  0.02114063

p_int:  0.790448441

p_ni:  0.209551559

Data Source:  BioPlex

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (2)

Downstream (1)

1 – 2 of 2

HCK

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Fc gamma R-mediated phagocytosis

LYN

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Fc gamma R-mediated phagocytosis

Pathways (148)

Reactome (14)

KEGG (10)

WikiPathways (124)

Adaptive Immune System (R-HSA-1280218)

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1 – 5 of 14

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Reactome	Cross-presentation of soluble exogenous antigens (endosomes)	51 targets	R-HSA-1236978
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Cross-presentation of soluble exogenous antigens (endosomes)	51 targets	R-HSA-1236978
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (1)

Components (4)

Processes (8)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
IgG binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (6)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	2	2	2		57.2
triglyceride measurement	EFO_0004530	3	2	3		54.1
heel bone mineral density	EFO_0009270	1	1	1		42.3
apolipoprotein A 1 measurement	EFO_0004614	2	2	2		38.1
BMI-adjusted hip circumference	EFO_0008039	1	1	1		15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	2		57.2
triglyceride measurement	EFO_0004530	3		54.1
heel bone mineral density	EFO_0009270	1		42.3
apolipoprotein A 1 measurement	EFO_0004614	2		38.1
BMI-adjusted hip circumference	EFO_0008039	1		15.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
IgG-binding protein
Immunity
Immunoglobulin domain

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
BMI-adjusted hip circumference
HbA1c measurement
heel bone mineral density
high density lipoprotein cholesterol measurement
triglyceride measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
immune system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	Fc receptor, IgG, high affinity I	MGI:95498	14129
Dog	Fc fragment of IgG, high affinity Ia, receptor (CD64)		403462
Cow	Fc fragment of IgG, high affinity Ia, receptor (CD64)		282227
Pig	Fc fragment of IgG, high affinity Ia, receptor (CD64)		613130

Species	Name	OMA	EggNOG	Inparanoid
Mouse	Fc receptor, IgG, high affinity I
Dog	Fc fragment of IgG, high affinity Ia, receptor (CD64)
Cow	Fc fragment of IgG, high affinity Ia, receptor (CD64)
Pig	Fc fragment of IgG, high affinity Ia, receptor (CD64)

Publication Statistics

PubMed Score 1375.90

PubMed score by year

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PubTator Score 1220.18

PubTator score by year

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Related Publications

Text Mined References (137)

GeneRif Annotations (107)

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PMID	Year	Title