Tclin FCGR1A High affinity immunoglobulin gamma Fc receptor I

Protein Summary

Description

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P12314
• P12315
• Q5QNW7
• Q92495
• Q92663
• IgG Fc receptor I

Gene Name

• FCGR1A

Ensembl ID

• ENST00000369168
• ENSP00000358165
• ENSG00000150337

Symbol

• FCG1
• FCGR1
• IGFR1
• CD64
• FCRI
• CD64A
• IGFR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
cellular component	0.88
drug	0.85
biological term	0.79
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / High Affinity Immunoglobulin Gamma Fc Receptor I

DTO Classes

Protein / Cell Adhesion / High Affinity Immunoglobulin Gamma Fc Receptor I

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1516.51   (req: < 5)

Gene RIFs: 129   (req: <= 3)

Antibodies: 1089   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1516.51   (req: >= 5)

Gene RIFs: 129   (req: > 3)

Antibodies: 1089   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1