You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
FCGR1A
High affinity immunoglobulin gamma Fc receptor I

Protein Classes
Protein Summary
Description
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369168
  • ENSP00000358165
  • ENSG00000150337

Symbol
  • FCG1
  • FCGR1
  • IGFR1
  • CD64
  • FCRI
  • CD64A
  • IGFR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
cellular component
0.88
drug
0.85
biological term
0.79
protein domain
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1357.29   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 1089   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1357.29   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 1089   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2377172
chemical structure image
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95498
14129
Dog
Fc fragment of IgG, high affinity Ia, receptor (CD64)
403462
Cow
Fc fragment of IgG, high affinity Ia, receptor (CD64)
282227
Pig
Fc fragment of IgG, high affinity Ia, receptor (CD64)
613130
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
Fc fragment of IgG, high affinity Ia, receptor (CD64)
Cow
Fc fragment of IgG, high affinity Ia, receptor (CD64)
Pig
Fc fragment of IgG, high affinity Ia, receptor (CD64)
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (148)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cross-presentation of soluble exogenous antigens (endosomes)
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cross-presentation of soluble exogenous antigens (endosomes)
Cytokine Signaling in Immune system
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (382)
1 – 10 of 382
ITIH2
Tbio
Novelty: 0.04886358
p_int: 0.99916906
p_ni: 0.000810464
p_wrong: 0.000020476
Score: 0.162
Data Source: BioPlex,STRINGDB
HBA1
Tclin
Novelty: 0.00094113
p_int: 0.995277328
p_ni: 0.004722661
p_wrong: 1.2e-8
Data Source: BioPlex
PCDH17
Tbio
Novelty: 0.03341603
p_int: 0.991269012
p_ni: 0.000388273
p_wrong: 0.008342715
Score: 0.823
Data Source: BioPlex,STRINGDB
PCDH12
Tbio
Novelty: 0.06268895
p_int: 0.989055834
p_ni: 0.000089016
p_wrong: 0.01085515
Score: 0.57
Data Source: BioPlex,STRINGDB
FREM2
Tbio
Novelty: 0.03382033
p_int: 0.965645975
p_ni: 0.034354025
Score: 0.183
Data Source: BioPlex,STRINGDB
PCDH7
Tbio
Novelty: 0.04017185
p_int: 0.96363898
p_ni: 0.03636102
Score: 0.795
Data Source: BioPlex,STRINGDB
CDC42BPA
Tchem
Family: Kinase
Novelty: 0.02575412
p_int: 0.849254386
p_ni: 0.150745614
Score: 0.195
Data Source: BioPlex,STRINGDB
ULBP3
Tbio
Novelty: 0.0320239
p_int: 0.830825743
p_ni: 0.168853352
p_wrong: 0.000320905
Score: 0.166
Data Source: BioPlex,STRINGDB
ACAD8
Tbio
Family: Enzyme
Novelty: 0.05735881
p_int: 0.819087734
p_ni: 0.180912266
Score: 0.189
Data Source: BioPlex,STRINGDB
FRAS1
Tbio
Novelty: 0.02114063
p_int: 0.790448441
p_ni: 0.209551559
Data Source: BioPlex
Publication Statistics
PubMed Score  1357.29

PubMed score by year
PubTator Score  1220.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer