FCGR1A
High affinity immunoglobulin gamma Fc receptor I
Protein Classes
Protein Summary
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]
- ENST00000369168
- ENSP00000358165
- ENSG00000150337
- FCG1
- FCGR1
- IGFR1
- CD64
- FCRI
- CD64A
- IGFR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
cellular component | 0.88 | ||
drug | 0.85 | ||
biological term | 0.79 | ||
protein domain | 0.73 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1357.29 (req: < 5)
Gene RIFs: 107 (req: <= 3)
Antibodies: 1089 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1357.29 (req: >= 5)
Gene RIFs: 107 (req: > 3)
Antibodies: 1089 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Orthologs (4)
1 – 4 of 4
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:95498 | 14129 | ||||||
Dog | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 403462 | ||||||
Cow | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 282227 | ||||||
Pig | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 613130 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Dog | Fc fragment of IgG, high affinity Ia, receptor (CD64) | |||||
Cow | Fc fragment of IgG, high affinity Ia, receptor (CD64) | |||||
Pig | Fc fragment of IgG, high affinity Ia, receptor (CD64) | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (148)
Reactome (14)
KEGG (10)
WikiPathways (124)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 14
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Cross-presentation of soluble exogenous antigens (endosomes) | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing-Cross presentation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Cross-presentation of soluble exogenous antigens (endosomes) | ||||
Cytokine Signaling in Immune system | ||||
Gene Ontology Terms (13)
Functions (1)
Components (4)
Processes (8)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (382)
1 – 10 of 382
ITIH2
Novelty: 0.04886358
p_int: 0.99916906
p_ni: 0.000810464
p_wrong: 0.000020476
Score: 0.162
Data Source: BioPlex,STRINGDB
HBA1
Novelty: 0.00094113
p_int: 0.995277328
p_ni: 0.004722661
p_wrong: 1.2e-8
Data Source: BioPlex
PCDH17
Novelty: 0.03341603
p_int: 0.991269012
p_ni: 0.000388273
p_wrong: 0.008342715
Score: 0.823
Data Source: BioPlex,STRINGDB
PCDH12
Novelty: 0.06268895
p_int: 0.989055834
p_ni: 0.000089016
p_wrong: 0.01085515
Score: 0.57
Data Source: BioPlex,STRINGDB
FREM2
Novelty: 0.03382033
p_int: 0.965645975
p_ni: 0.034354025
Score: 0.183
Data Source: BioPlex,STRINGDB
PCDH7
Novelty: 0.04017185
p_int: 0.96363898
p_ni: 0.03636102
Score: 0.795
Data Source: BioPlex,STRINGDB
CDC42BPA
Family: Kinase
Novelty: 0.02575412
p_int: 0.849254386
p_ni: 0.150745614
Score: 0.195
Data Source: BioPlex,STRINGDB
ULBP3
Novelty: 0.0320239
p_int: 0.830825743
p_ni: 0.168853352
p_wrong: 0.000320905
Score: 0.166
Data Source: BioPlex,STRINGDB
ACAD8
Family: Enzyme
Novelty: 0.05735881
p_int: 0.819087734
p_ni: 0.180912266
Score: 0.189
Data Source: BioPlex,STRINGDB
FRAS1
Novelty: 0.02114063
p_int: 0.790448441
p_ni: 0.209551559
Data Source: BioPlex
Publication Statistics
PubMed Score 1357.29
PubMed score by year
PubTator Score 1220.18
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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