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Tbio
PTHLH
Parathyroid hormone-related protein

Protein Summary
Description
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1. Osteos ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000201015
  • ENSP00000201015
  • ENSG00000087494
  • ENST00000395868
  • ENSP00000379209
  • ENST00000395872
  • ENSP00000379213
  • ENST00000535992
  • ENSP00000440613
  • ENST00000538310
  • ENSP00000441890
  • ENST00000539239
  • ENSP00000441571
  • ENST00000545234
  • ENSP00000441765

Symbol
  • PTHRP
  • HHM
  • PLP
  • BDE2
  • PTHR
  • PTHRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
biological process
0.91
PubMedID
0.86
transcription factor perturbation
0.84
chemical
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2435.06   (req: < 5)
Gene RIFs: 158   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2435.06   (req: >= 5)
Gene RIFs: 158   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0