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Tbio
RLBP1
Retinaldehyde-binding protein 1

Protein Summary
Description
Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268125
  • ENSP00000268125
  • ENSG00000140522

Symbol
  • CRALBP
  • CRALBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.67
cell line
0.54
PubMedID
0.53
biological term
0.49
kinase perturbation
0.48


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.98   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.98   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinaldehyde binding protein 1
VGNC:1888
453635
Macaque
retinaldehyde binding protein 1
699510
Mouse
MGI:97930
19771
Rat
RGD:1309649
293049
Dog
retinaldehyde binding protein 1
VGNC:45603
479039
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinaldehyde binding protein 1
Macaque
retinaldehyde binding protein 1
Mouse
Rat
Dog
retinaldehyde binding protein 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12271-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (86)
1 – 10 of 86
RPE65
Tbio
Family: Enzyme
Novelty: 0.00147985
Score: 0.988
Data Source: STRINGDB
RDH5
Tbio
Family: Enzyme
Novelty: 0.0111079
Score: 0.983
Data Source: Reactome,STRINGDB
RDH11
Tbio
Family: Enzyme
Novelty: 0.02758936
Score: 0.975
Data Source: Reactome,STRINGDB
SDR9C7
Tbio
Family: Enzyme
Novelty: 0.01618496
Score: 0.963
Data Source: STRINGDB
RDH10
Tbio
Family: Enzyme
Novelty: 0.03049914
Score: 0.961
Data Source: Reactome,STRINGDB
AWAT2
Tbio
Family: Enzyme
Novelty: 0.00986244
Score: 0.922
Data Source: Reactome,STRINGDB
RDH16
Tbio
Family: Enzyme
Novelty: 0.08211372
Score: 0.919
Data Source: STRINGDB
HSD17B6
Tbio
Family: Enzyme
Novelty: 0.01428594
Score: 0.907
Data Source: STRINGDB
DHRS9
Tbio
Family: Enzyme
Novelty: 0.00256743
Score: 0.904
Data Source: STRINGDB
DEGS1
Tchem
Family: Enzyme
Novelty: 0.00300325
Score: 0.82
Data Source: STRINGDB
Publication Statistics
PubMed Score  188.98

PubMed score by year
PubTator Score  90.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer