Tbio TPR Nucleoprotein TPR

Protein Summary

Description

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P12270
• Q15624
• Q15655
• Q5SWY0
• Q99968

Gene Name

• TPR

Ensembl ID

• ENST00000367478
• ENSP00000356448
• ENSG00000047410
• ENST00000613151
• ENSP00000483425

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
protein complex	1
drug perturbation	0.96
cellular component	0.95
co-expressed gene	0.95

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.87   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.87   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	translocated promoter region, nuclear basket protein	VGNC:9903	457588
Mouse	translocated promoter region, nuclear basket protein	MGI:1922066	108989
Rat	translocated promoter region, nuclear basket protein	RGD:1310664	304862
Dog	translocated promoter region, nuclear basket protein	VGNC:53807	480045
Horse	translocated promoter region, nuclear basket protein	VGNC:50899	100049850

Species	Name	OMA	EggNOG	Inparanoid
Chimp	translocated promoter region, nuclear basket protein
Mouse	translocated promoter region, nuclear basket protein
Rat	translocated promoter region, nuclear basket protein
Dog	translocated promoter region, nuclear basket protein
Horse	translocated promoter region, nuclear basket protein

Protein Structure (4 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12270-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (72)

Reactome (68)

KEGG (3)

WikiPathways (1)

Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Items per page:

5

1 – 5 of 68

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cellular response to heat stress	100 targets	R-HSA-3371556
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cellular response to heat stress	100 targets	R-HSA-3371556
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Gene Ontology Terms (45)

Functions (9)

Components (13)

Processes (23)

Find Similar Targets

Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	UniProtKB
dynein complex binding	Inferred from Direct Assay (IDA)	UniProtKB
heat shock protein binding	Inferred from Direct Assay (IDA)	UniProtKB
mitogen-activated protein kinase binding	Inferred from Direct Assay (IDA)	UniProtKB
mRNA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
structural constituent of nuclear pore	Inferred from Direct Assay (IDA)	UniProtKB
tubulin binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (348)

Explore Interacting Targets

1 – 10 of 348

• See Interactions on String-DB

ZC3HC1

Tbio

Novelty:  0.089692

p_int:  0.991915462

p_ni:  0.008084538

Score:  0.407

Data Source:  BioPlex,STRINGDB

NUP153

Tbio

Novelty:  0.00696568

Score:  0.994

Data Source:  STRINGDB

NUP107

Tbio

Novelty:  0.01994155

Score:  0.992

Data Source:  STRINGDB

NUP98

Tbio

Family:  Enzyme

Novelty:  0.00401452

Score:  0.991

Data Source:  STRINGDB

U2AF2

Tbio

Novelty:  0.00590935

Score:  0.987

Data Source:  STRINGDB

NUP205

Tbio

Novelty:  0.06778513

Score:  0.985

Data Source:  STRINGDB

NUP93

Tbio

Novelty:  0.0248311

Score:  0.984

Data Source:  STRINGDB

NXF1

Tbio

Novelty:  0.00642439

Score:  0.983

Data Source:  STRINGDB

NUP62

Tbio

Novelty:  0.01432724

Score:  0.982

Data Source:  STRINGDB

RANBP2

Tbio

Family:  Enzyme

Novelty:  0.00484823

Score:  0.981

Data Source:  STRINGDB

Publication Statistics

PubMed Score  221.87

PubMed score by year

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PubTator Score  372.71

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell cycle
Cell division
Centromere
Chromosomal rearrangement
Chromosome
Coiled coil
Complete proteome

MGI Phenotype Find Similar Targets

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mortality/aging