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Tclin
IMPDH2
Inosine-5'-monophosphate dehydrogenase 2

Protein Summary
Description
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326739
  • ENSP00000321584
  • ENSG00000178035

Symbol
  • IMPD2
  • IMPD2
  • IMPDH-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
transcription factor perturbation
0.97
small molecule perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.83   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.83   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 491
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (491)
Protein-Protein Interactions (218)
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.971
Data Source:  BioPlex,STRINGDB
ANKRD9
Tdark
Novelty:  0.43181793
p_int:  0.998647425
p_ni:  0.001350326
p_wrong:  0.00000225
Score:  0.933
Data Source:  BioPlex,STRINGDB
SLC25A44
Tdark
Family:  Transporter
Novelty:  0.36924538
p_int:  0.998471197
p_ni:  0.001528803
Score:  0.847
Data Source:  BioPlex,STRINGDB
SMCR8
Tbio
Novelty:  0.11500348
p_int:  0.998218405
p_ni:  0.001525461
p_wrong:  0.000256134
Score:  0.869
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.991856857
p_ni:  0.008143143
Score:  0.227
Data Source:  BioPlex,STRINGDB
PUSL1
Tdark
Family:  Enzyme
Novelty:  2.39739964
p_int:  0.964596796
p_ni:  0.035353319
p_wrong:  0.000049885
Score:  0.787
Data Source:  BioPlex,STRINGDB
GMPS
Tbio
Family:  Enzyme
Novelty:  0.00611806
Score:  0.995
Data Source:  STRINGDB
CTPS1
Tbio
Family:  Enzyme
Novelty:  0.00911596
Score:  0.979
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.966
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of nucleotides
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
2
0
1.1
86.6
body fat distribution
2
1
4
81
BMI-adjusted waist-hip ratio
1
1
1
78.1
mood instability measurement
2
2
1
5.9
77.6
self reported educational attainment
3
3
3
76.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1.1
86.6
body fat distribution
4
81
BMI-adjusted waist-hip ratio
1
78.1
mood instability measurement
1
5.9
77.6
self reported educational attainment
3
76.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inosine monophosphate dehydrogenase 2
VGNC:11978
460362
Macaque
inosine monophosphate dehydrogenase 2
708307
Mouse
MGI:109367
23918
Rat
RGD:735092
301005
Dog
inosine monophosphate dehydrogenase 2
VGNC:42011
476630
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inosine monophosphate dehydrogenase 2
Macaque
inosine monophosphate dehydrogenase 2
Mouse
Rat
Dog
inosine monophosphate dehydrogenase 2
Publication Statistics
PubMed Score 143.83
PubMed score by year
PubTator Score 94.62
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title