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Tchem
SLC25A6
ADP/ATP translocase 3

Protein Summary
Description
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381401
  • ENSP00000370808
  • ENSG00000169100

Symbol
  • ANT3
  • ANT
  • AAC3
  • ANT3
  • ANT 2
  • ANT 3
  • ANT3Y
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.98
molecular function
0.88
biological process
0.84
cellular component
0.76


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.74   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.74   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
gilteritinib
Rendered image for gilteritinib
Active Ligands (1)
1 – 1 of 1
masitinib
Rendered image for masitinib
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
70.2
mitochondrial heteroplasmy measurement
1
1
1
65.4
lymphocyte percentage of leukocytes
1
1
1
60.5
lymphocyte count
1
1
1
57.8
mean reticulocyte volume
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
70.2
mitochondrial heteroplasmy measurement
1
65.4
lymphocyte percentage of leukocytes
1
60.5
lymphocyte count
1
57.8
mean reticulocyte volume
1
48.5
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Cow
solute carrier family 25 member 6
VGNC:49967
282480
Species
Name
OMA
EggNOG
Inparanoid
Cow
solute carrier family 25 member 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P12236-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (25)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Reactome
Host Interactions with Influenza Factors
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Disease
HIV Infection
Host Interactions of HIV factors
Host Interactions with Influenza Factors
Infectious disease
Protein-Protein Interactions (173)
1 – 10 of 173
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.975870222
p_ni:  0.024129778
Data Source:  BioPlex
FAM187B
Tdark
Novelty:  0.59092623
p_int:  0.975128989
p_ni:  0.024871011
Score:  0.204
Data Source:  BioPlex,STRINGDB
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.969254923
p_ni:  0.030745077
Data Source:  BioPlex
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.959328918
p_ni:  0.040671082
Data Source:  BioPlex
CLEC4C
Tbio
Novelty:  0.00845053
p_int:  0.945077329
p_ni:  0.054922671
Data Source:  BioPlex
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.939038617
p_ni:  0.060961383
Score:  0.164
Data Source:  BioPlex,STRINGDB
ORAI1
Tchem
Family:  IC
Novelty:  0.00179685
p_int:  0.936370651
p_ni:  0.063629349
Data Source:  BioPlex
VSIG4
Tbio
Novelty:  0.01671671
p_int:  0.935868335
p_ni:  0.064131665
Data Source:  BioPlex
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.93530661
p_ni:  0.06469339
Data Source:  BioPlex
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.935169694
p_ni:  0.064830306
Data Source:  BioPlex
Publication Statistics
PubMed Score  199.74

PubMed score by year
PubTator Score  842.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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