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Tbio
SLC25A4
ADP/ATP translocase 1

Protein Summary
Description
Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281456
  • ENSP00000281456
  • ENSG00000151729

Symbol
  • ANT1
  • T1
  • ANT
  • AAC1
  • ANT1
  • PEO2
  • PEO3
  • ANT 1
  • PEOA2
  • MTDPS12
  • MTDPS12A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
transcription factor binding site profile
0.9
PubMedID
0.88
disease perturbation
0.87
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.74   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.74   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (45)
Disease (R-HSA-1643685)

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Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Reactome
Infectious disease
Reactome
Interactions of Vpr with host cellular proteins
Name
Explore in Pharos
Explore in Source
Disease
HIV Infection
Host Interactions of HIV factors
Infectious disease
Interactions of Vpr with host cellular proteins
Protein-Protein Interactions (181)
1 – 10 of 181
OSTM1
Tbio
Novelty: 0.04716423
p_int: 0.9755661
p_ni: 0.0244339
Data Source: BioPlex
ISLR
Tbio
Novelty: 0.10472842
p_int: 0.926953565
p_ni: 0.073046435
Score: 0.207
Data Source: BioPlex,STRINGDB
ORAI1
Tchem
Family: IC
Novelty: 0.00209003
p_int: 0.901441584
p_ni: 0.098558416
Data Source: BioPlex
SCGB2A2
Tbio
Novelty: 0.01762536
p_int: 0.900626011
p_ni: 0.099373989
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.08368201
p_int: 0.88440356
p_ni: 0.11559644
Data Source: BioPlex
TMEM9
Tbio
Novelty: 0.1192335
p_int: 0.868370788
p_ni: 0.131629212
Data Source: BioPlex
KLK1
Tchem
Family: Enzyme
Novelty: 0.00205352
p_int: 0.834736552
p_ni: 0.165263448
Data Source: BioPlex
NRBP1
Tbio
Family: Kinase
Novelty: 0.08101852
p_int: 0.822713262
p_ni: 0.177286738
Data Source: BioPlex
CLEC4C
Tbio
Novelty: 0.01109083
p_int: 0.820663181
p_ni: 0.179336819
Data Source: BioPlex
OPALIN
Tdark
Novelty: 0.06813417
p_int: 0.811201085
p_ni: 0.188798915
Data Source: BioPlex
Publication Statistics
PubMed Score  91.74

PubMed score by year
PubTator Score  124.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer