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Tbio
COL11A1
Collagen alpha-1(XI) chain

Protein Summary
Description
May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353414
  • ENSP00000302551
  • ENSG00000060718
  • ENST00000358392
  • ENSP00000351163
  • ENST00000370096
  • ENSP00000359114
  • ENST00000512756
  • ENSP00000426533

Symbol
  • COLL6
  • STL2
  • COLL6
  • CO11A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.88
phenotype
0.78
disease
0.75
gene perturbation
0.71
small molecule perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.76   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.76   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, hip
3
3
0
1.1
90.3
intelligence
3
5
1
5.9
88.8
primary angle closure glaucoma
1
1
0
1.2
86.9
BMI-adjusted waist-hip ratio
1
1
1
84
heel bone mineral density
2
1
2
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
osteoarthritis, hip
0
1.1
90.3
intelligence
1
5.9
88.8
primary angle closure glaucoma
0
1.2
86.9
BMI-adjusted waist-hip ratio
1
84
heel bone mineral density
2
82.3
Pathways (84)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (27)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (126)
1 – 10 of 126
COL5A2
Tbio
Novelty: 0.01352973
Score: 0.949
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.945
Data Source: STRINGDB
LUM
Tbio
Novelty: 0.00219939
Score: 0.94
Data Source: STRINGDB
COL6A1
Tbio
Novelty: 0.00644855
Score: 0.939
Data Source: STRINGDB
COL12A1
Tbio
Novelty: 0.0239421
Score: 0.939
Data Source: STRINGDB
COL9A3
Tbio
Novelty: 0.02556037
Score: 0.937
Data Source: STRINGDB
ADAMTS2
Tbio
Family: Enzyme
Novelty: 0.00852208
Score: 0.937
Data Source: STRINGDB
COL4A1
Tbio
Novelty: 0.00358049
Score: 0.937
Data Source: STRINGDB
COL9A2
Tbio
Novelty: 0.01711515
Score: 0.936
Data Source: STRINGDB
COL4A2
Tbio
Novelty: 0.00782053
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  175.76

PubMed score by year
PubTator Score  113.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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