COL11A1
Collagen alpha-1(XI) chain
Protein Summary
May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
- ENST00000353414
- ENSP00000302551
- ENSG00000060718
- ENST00000358392
- ENSP00000351163
- ENST00000370096
- ENSP00000359114
- ENST00000512756
- ENSP00000426533
- COLL6
- STL2
- COLL6
- CO11A1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.88 | ||
phenotype | 0.78 | ||
disease | 0.75 | ||
gene perturbation | 0.71 | ||
small molecule perturbation | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 219.66 (req: < 5)
Gene RIFs: 99 (req: <= 3)
Antibodies: 121 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 219.66 (req: >= 5)
Gene RIFs: 99 (req: > 3)
Antibodies: 121 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0