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Tbio
COL11A1
Collagen alpha-1(XI) chain

Protein Summary
Description
May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353414
  • ENSP00000302551
  • ENSG00000060718
  • ENST00000358392
  • ENSP00000351163
  • ENST00000370096
  • ENSP00000359114
  • ENST00000512756
  • ENSP00000426533

Symbol
  • COLL6
  • STL2
  • COLL6
  • CO11A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.88
phenotype
0.78
disease
0.75
gene perturbation
0.71
small molecule perturbation
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.31   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.31   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
COL5A2
Tbio
Novelty:  0.01352973
Score:  0.949
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.945
Data Source:  STRINGDB
LUM
Tbio
Novelty:  0.00219939
Score:  0.94
Data Source:  STRINGDB
COL6A1
Tbio
Novelty:  0.00644855
Score:  0.939
Data Source:  STRINGDB
COL12A1
Tbio
Novelty:  0.0239421
Score:  0.939
Data Source:  STRINGDB
COL9A3
Tbio
Novelty:  0.02556037
Score:  0.937
Data Source:  STRINGDB
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
Score:  0.937
Data Source:  STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.937
Data Source:  STRINGDB
COL9A2
Tbio
Novelty:  0.01711515
Score:  0.936
Data Source:  STRINGDB
COL4A2
Tbio
Novelty:  0.00782053
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (84)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
19
19
89.4
3
3
0
1.1
79.8
1
1
0
1.2
75.9
BMI-adjusted waist-hip ratio
3
4
5
74.8
waist-hip ratio
2
2
2
73.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
19
89.4
0
1.1
79.8
0
1.2
75.9
BMI-adjusted waist-hip ratio
5
74.8
waist-hip ratio
2
73.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
collagen type XI alpha 1 chain
712753
Mouse
MGI:88446
12814
Rat
RGD:2372
25654
Dog
collagen type XI alpha 1 chain
VGNC:39456
100685969
Horse
collagen type XI alpha 1 chain
VGNC:16721
100049922
Species
Name
OMA
EggNOG
Inparanoid
Macaque
collagen type XI alpha 1 chain
Mouse
Rat
Dog
collagen type XI alpha 1 chain
Horse
collagen type XI alpha 1 chain
Publication Statistics
PubMed Score 191.31
PubMed score by year
PubTator Score 113.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title