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Tchem
FABP2
Fatty acid-binding protein, intestinal

Protein Summary
Description
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and proliferation. This protein binds saturated long-chain fatty acids with high affinity, and may act as a lipid sensor to maintain energy homeostasis. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274024
  • ENSP00000274024
  • ENSG00000145384

Symbol
  • FABPI
  • FABPI
  • I-FABP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.74
biological term
0.71
gene perturbation
0.68
cell type or tissue
0.67
microRNA
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 576.26   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 526   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 576.26   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
28.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
28.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 2
VGNC:7045
740421
Mouse
MGI:95478
14079
Rat
RGD:2591
25598
Dog
fatty acid binding protein 2
VGNC:40560
487924
Horse
fatty acid binding protein 2
VGNC:17767
100034050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fatty acid binding protein 2
Mouse
Rat
Dog
fatty acid binding protein 2
Horse
fatty acid binding protein 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12104-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Triglyceride catabolism
Reactome
Triglyceride metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Triglyceride catabolism
Triglyceride metabolism
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (57)
1 – 10 of 57
GOT2
Tbio
Family: Enzyme
Novelty: 0.00054023
Score: 0.926
Data Source: STRINGDB
LIPE
Tchem
Family: Enzyme
Novelty: 0.00169872
Score: 0.926
Data Source: STRINGDB
FABP1
Tchem
Novelty: 0.00192691
Score: 0.925
Data Source: STRINGDB
FABP4
Tchem
Novelty: 0.00107707
Score: 0.912
Data Source: STRINGDB
FABP6
Tbio
Novelty: 0.00671588
Score: 0.843
Data Source: STRINGDB
MANBA
Tchem
Family: Enzyme
Novelty: 0.00961026
Score: 0.715
Data Source: STRINGDB
INSIG2
Tbio
Novelty: 0.00980894
Score: 0.714
Data Source: STRINGDB
AGR2
Tbio
Novelty: 0.00621485
Score: 0.697
Data Source: STRINGDB
GATA5
Tbio
Family: TF
Novelty: 0.00759873
Score: 0.647
Data Source: STRINGDB
MLXIPL
Tbio
Family: TF
Novelty: 0.00357389
Score: 0.629
Data Source: STRINGDB
Publication Statistics
PubMed Score  576.26

PubMed score by year
PubTator Score  393.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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