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Tchem
HARS
Histidine--tRNA ligase, cytoplasmic

Protein Summary
Description
Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307633
  • ENSP00000304668
  • ENSG00000170445
  • ENST00000438307
  • ENSP00000411511
  • ENST00000457527
  • ENSP00000387893
  • ENST00000504156
  • ENSP00000425634
  • ENST00000644191
  • ENSP00000495156

Symbol
  • HRS
  • HRS
  • CMT2W
  • USH3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
protein domain
0.92
kinase perturbation
0.91
molecular function
0.88
histone modification site profile
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.26   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.26   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL412891
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
1
3
62.4
self reported educational attainment
1
1
1
56.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
62.4
self reported educational attainment
1
56.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histidyl-tRNA synthetase
VGNC:4028
737554
Mouse
MGI:108087
15115
Rat
RGD:1310695
307492
Dog
histidyl-tRNA synthetase
VGNC:41597
478034
Horse
histidyl-tRNA synthetase
VGNC:18694
100061748
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histidyl-tRNA synthetase
Mouse
Rat
Dog
histidyl-tRNA synthetase
Horse
histidyl-tRNA synthetase
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism of proteins
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism of proteins
Translation
tRNA Aminoacylation
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (165)
1 – 10 of 165
HARS2
Tbio
Family: Enzyme
Novelty: 0.00230399
p_int: 0.999805545
p_ni: 0.000194455
Score: 0.84
Data Source: BioPlex,STRINGDB
SGCZ
Tbio
Novelty: 0.08511312
p_int: 0.971870221
p_ni: 0.028129779
Score: 0.534
Data Source: BioPlex,STRINGDB
KARS
Tchem
Family: Enzyme
Novelty: 0.00386511
Score: 0.973
Data Source: STRINGDB
AARS
Tbio
Family: Enzyme
Novelty: 0.00203732
Score: 0.969
Data Source: STRINGDB
YARS
Tchem
Family: Enzyme
Novelty: 0.00302115
Score: 0.964
Data Source: STRINGDB
GCN1
Tbio
Novelty: 0.02721216
Score: 0.96
Data Source: STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.958
Data Source: STRINGDB
GARS
Tbio
Family: Enzyme
Novelty: 0.00190498
Score: 0.947
Data Source: STRINGDB
TARS
Tchem
Family: Enzyme
Novelty: 0.00795387
Score: 0.946
Data Source: STRINGDB
TARSL2
Tbio
Family: Enzyme
Novelty: 0.02406282
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  67.26

PubMed score by year
PubTator Score  103.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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