Tchem HARS Histidine--tRNA ligase, cytoplasmic

Protein Summary

Description

Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• P12081
• B4DHQ1
• B4DY73
• D6REN6
• J3KNE5

Gene Name

• HARS

Ensembl ID

• ENST00000307633
• ENSP00000304668
• ENSG00000170445
• ENST00000438307
• ENSP00000411511
• ENST00000457527
• ENSP00000387893
• ENST00000504156
• ENSP00000425634
• ENST00000644191
• ENSP00000495156

Symbol

• HRS
• HRS
• CMT2W
• USH3B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
protein domain	0.92
kinase perturbation	0.91
molecular function	0.88
histone modification site profile	0.87

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Histidine--trna Ligase, Cytoplasmic

Protein / Ligase / Aminoacyl-trna Synthetase / Histidine--trna Ligase, Cytoplasmic

DTO Classes

Protein / Enzyme / Ligase / Aminoacyl-trna Synthetase / Histidine--trna Ligase, Cytoplasmic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.99   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.99   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0