Tbio COX6A1 Cytochrome c oxidase subunit 6A1, mitochondrial

Protein Summary

Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P12074
• B2R500
• O43714
• Q32Q37

Gene Name

• COX6A1

Ensembl ID

• ENST00000229379
• ENSP00000229379
• ENSG00000111775

Symbol

• COX6AL
• COX6A
• CMTRID
• COX6AL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
kinase perturbation	0.98
co-expressed gene	0.89
transcription factor binding site profile	0.79
cellular component	0.67

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Cytochrome C Oxidase Subunit 6a1, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Cytochrome C Oxidase Subunit 6a1, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.1   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.1   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0