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Tbio
FGF5
Fibroblast growth factor 5

Protein Summary
Description
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity). The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312465
  • ENSP00000311697
  • ENSG00000138675
  • ENST00000456523
  • ENSP00000398353

Symbol
  • HBGF-5
  • TCMGLY
  • Smag-82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.87
gene perturbation
0.77
histone modification site profile
0.67
microRNA
0.67
transcription factor
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.31   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.31   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
4
4
97
diastolic blood pressure
9
8
20
96.8
2
7
8
94.9
Alopecia
1
4
4
91.7
glomerular filtration rate
6
3
6
7.4
91.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
4
97
diastolic blood pressure
20
96.8
8
94.9
Alopecia
4
91.7
glomerular filtration rate
6
7.4
91.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 5 [Source:HGNC Symbol;Acc:HGNC:3683]
Mouse
MGI:95519
14176
Rat
RGD:620129
60662
Dog
fibroblast growth factor 5
VGNC:40851
608459
Horse
fibroblast growth factor 5
VGNC:18018
100060219
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 5 [Source:HGNC Symbol;Acc:HGNC:3683]
Mouse
Rat
Dog
fibroblast growth factor 5
Horse
fibroblast growth factor 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P12034-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (91)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 65
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (103)
1 – 10 of 103
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
Score:  0.948
Data Source:  STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
Score:  0.945
Data Source:  STRINGDB
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
Score:  0.933
Data Source:  STRINGDB
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
Score:  0.886
Data Source:  STRINGDB
EGF
Tbio
Novelty:  0.00010809
Score:  0.858
Data Source:  STRINGDB
KDR
Tclin
Family:  Kinase
Novelty:  0.00016219
Score:  0.839
Data Source:  STRINGDB
FLT1
Tclin
Family:  Kinase
Novelty:  0.00039648
Score:  0.8
Data Source:  STRINGDB
KRT71
Tbio
Novelty:  0.06565294
Score:  0.8
Data Source:  STRINGDB
PDGFRA
Tclin
Family:  Kinase
Novelty:  0.00066909
Score:  0.776
Data Source:  STRINGDB
PDGFRB
Tclin
Family:  Kinase
Novelty:  0.00074896
Score:  0.765
Data Source:  STRINGDB
Publication Statistics
PubMed Score  174.31

PubMed score by year
PubTator Score  60.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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