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Tchem
PCNA
Proliferating cell nuclear antigen

Protein Summary
Description
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. The protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379143
  • ENSP00000368438
  • ENSG00000132646
  • ENST00000379160
  • ENSP00000368458

Symbol
  • ATLD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
co-expressed gene
1
hub protein
1
molecular function
0.94
transcription factor binding site profile
0.94


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.69   (req: < 5)
Gene RIFs: 328   (req: <= 3)
Antibodies: 2300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.69   (req: >= 5)
Gene RIFs: 328   (req: > 3)
Antibodies: 2300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proliferating cell nuclear antigen
VGNC:6229
458081
Macaque
proliferating cell nuclear antigen
718006
Mouse
MGI:97503
18538
Mouse
MGI:97505
18540
Rat
RGD:3269
25737
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proliferating cell nuclear antigen
Macaque
proliferating cell nuclear antigen
Mouse
Mouse
Rat
Protein Structure (32 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12004-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 32
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (108)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 63
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Damage Bypass
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Damage Bypass
Gene Ontology Terms (57)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (551)
1 – 10 of 551
FEN1
Tchem
Family: Enzyme
Novelty: 0.00082515
p_int: 0.999924849
p_ni: 0.000075151
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PCLAF
Tbio
Novelty: 0.00328133
p_int: 0.999594644
p_ni: 0.000405356
Score: 0.997
Data Source: BioPlex,STRINGDB
CCNE1
Tchem
Novelty: 0.00237201
p_int: 0.998873777
p_ni: 0.000097202
p_wrong: 0.001029021
Score: 0.991
Data Source: BioPlex,STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.996352886
p_ni: 0.003647114
Score: 0.921
Data Source: BioPlex,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.995200662
p_ni: 0.004799338
Score: 0.994
Data Source: BioPlex,STRINGDB
FANCM
Tbio
Novelty: 0.01122278
p_int: 0.993858826
p_ni: 0.006141174
Score: 0.934
Data Source: BioPlex,STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
p_int: 0.989609886
p_ni: 0.010390114
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
p_int: 0.90507448
p_ni: 0.094925439
p_wrong: 8.1e-8
Score: 0.937
Data Source: BioPlex,STRINGDB
CCNE2
Tbio
Novelty: 0.00795182
p_int: 0.889944577
p_ni: 0.000123419
p_wrong: 0.109932004
Score: 0.931
Data Source: BioPlex,STRINGDB
RFC4
Tbio
Novelty: 0.03232586
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.69

PubMed score by year
PubTator Score  4943.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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