Protein Summary
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
- ENST00000234111
- ENSP00000234111
- ENSG00000115758
- ENST00000405333
- ENSP00000385333
- ODC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 1 | ||
chemical | 0.97 | ||
protein domain | 0.97 | ||
transcription factor binding site profile | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2793.62 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 817 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2793.62 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 817 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (2)
Protein-Protein Interactions (166)
OAZ3
Family: Enzyme
Novelty: 0.02374168
p_int: 0.999999997
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.984
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (17)
Reactome (4)
KEGG (3)
PathwayCommons (5)
UniProt (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Metabolism of polyamines | ||||
Reactome | Regulation of ornithine decarboxylase (ODC) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Metabolism of polyamines | ||||
Regulation of ornithine decarboxylase (ODC) | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ornithine decarboxylase 1 | VGNC:329 | 459027 | |||||
Macaque | ornithine decarboxylase 1 | 695625 | ||||||
Mouse | MGI:97402 | 18263 | ||||||
Rat | RGD:3227 | 24609 | ||||||
Dog | ornithine decarboxylase 1 | VGNC:44097 | 475666 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ornithine decarboxylase 1 | |||||
Macaque | ornithine decarboxylase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ornithine decarboxylase 1 | |||||
Publication Statistics
PubMed Score 2793.62
PubMed score by year
PubTator Score 1998.03
PubTator score by year
Related Publications
Text Mined References (85)
GeneRif Annotations (55)
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