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Tbio
PRPS2
Ribose-phosphate pyrophosphokinase 2

Protein Summary
Description
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380668
  • ENSP00000370043
  • ENSG00000101911
  • ENST00000398491
  • ENSP00000381504

Symbol
  • PRSII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.99
disease perturbation
0.95
kinase perturbation
0.84
virus perturbation
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.54   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.54   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97776
110639
Rat
RGD:3415
24689
Dog
phosphoribosyl pyrophosphate synthetase 2
VGNC:45033
476855
Horse
phosphoribosyl pyrophosphate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:9465]
Pig
phosphoribosyl pyrophosphate synthetase 2
100510993
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phosphoribosyl pyrophosphate synthetase 2
Horse
phosphoribosyl pyrophosphate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:9465]
Pig
phosphoribosyl pyrophosphate synthetase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P11908-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
5-Phosphoribose 1-diphosphate biosynthesis (R-HSA-73843)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
5-Phosphoribose 1-diphosphate biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
5-Phosphoribose 1-diphosphate biosynthesis
Metabolism
Metabolism of carbohydrates
Pentose phosphate pathway
Gene Ontology Terms (19)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (86)
1 – 10 of 86
PRPSAP2
Tbio
Family: Enzyme
Novelty: 0.12017454
p_int: 1
Score: 0.962
Data Source: BioPlex,STRINGDB
PRPS1
Tbio
Family: Kinase
Novelty: 0.01139656
p_int: 0.999999997
p_ni: 3e-9
Score: 0.973
Data Source: BioPlex,STRINGDB
PRPSAP1
Tbio
Family: Enzyme
Novelty: 0.08377292
p_int: 0.99999921
p_ni: 7.9e-7
Score: 0.959
Data Source: BioPlex,STRINGDB
NMT2
Tchem
Family: Enzyme
Novelty: 0.04826835
p_int: 0.993852898
p_ni: 0.006147099
p_wrong: 3e-9
Score: 0.758
Data Source: BioPlex,STRINGDB
CARTPT
Tbio
Novelty: 0.00224864
p_int: 0.900877102
p_ni: 0.099122898
Data Source: BioPlex
INPP5A
Tchem
Family: Enzyme
Novelty: 0.03249263
p_int: 0.813974026
p_ni: 0.185187164
p_wrong: 0.00083881
Score: 0.243
Data Source: BioPlex,STRINGDB
PRIM2
Tbio
Family: Enzyme
Novelty: 0.05145449
p_int: 0.779208487
p_ni: 0.220791512
p_wrong: 1e-9
Score: 0.25
Data Source: BioPlex,STRINGDB
HLA-DQB2
Tbio
Novelty: 0.07062006
p_int: 0.77691088
p_ni: 0.22308912
Score: 0.197
Data Source: BioPlex,STRINGDB
PPAT
Tclin
Family: Enzyme
Novelty: 0.01549862
Score: 0.987
Data Source: STRINGDB
TKTL2
Tbio
Family: Enzyme
Novelty: 0.0915871
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.54

PubMed score by year
PubTator Score  16.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer