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Tclin
MS4A1
B-lymphocyte antigen CD20

Protein Summary
Description
This protein may be involved in the regulation of B-cell activation and proliferation. This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345732
  • ENSP00000314620
  • ENSG00000156738
  • ENST00000389939
  • ENSP00000374589
  • ENST00000528313
  • ENSP00000432270
  • ENST00000534668
  • ENSP00000433277

Symbol
  • CD20
  • B1
  • S7
  • Bp35
  • CD20
  • CVID5
  • MS4A2
  • LEU-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
cell line
0.73
kinase
0.63
microRNA
0.56
PubMedID
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.66   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 3294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.66   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 3294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (67)
1 – 10 of 67
MS4A3
Tbio
Novelty:  0.05521485
Score:  0.904
Data Source:  STRINGDB
CD19
Tclin
Novelty:  0.0001816
Score:  0.834
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.811
Data Source:  STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.77
Data Source:  STRINGDB
MS4A7
Tdark
Novelty:  1.1093531
Score:  0.767
Data Source:  STRINGDB
FCER2
Tchem
Novelty:  0.00209405
Score:  0.693
Data Source:  STRINGDB
IGLC1
Tdark
Novelty:  0.00459259
Score:  0.677
Data Source:  STRINGDB
FCRLA
Tbio
Novelty:  0.02364211
Score:  0.677
Data Source:  STRINGDB
IGLL5
Tbio
Novelty:  0.00459259
Score:  0.677
Data Source:  STRINGDB
CD22
Tclin
Novelty:  0.0009372
Score:  0.655
Data Source:  STRINGDB
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
82.7
monocyte count
1
1
1
79.5
monocyte percentage of leukocytes
1
1
1
65.4
response to radiation
1
1
1
38.2
ferritin measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
82.7
monocyte count
1
79.5
monocyte percentage of leukocytes
1
65.4
response to radiation
1
38.2
ferritin measurement
1
31.4
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane spanning 4-domains A1
VGNC:7669
451223
Macaque
membrane spanning 4-domains A1
696843
Mouse
MGI:88321
12482
Rat
RGD:1311999
309217
Dog
membrane spanning 4-domains A1
VGNC:52268
485430
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane spanning 4-domains A1
Macaque
membrane spanning 4-domains A1
Mouse
Rat
Dog
membrane spanning 4-domains A1
Publication Statistics
PubMed Score 132.66
PubMed score by year
PubTator Score 590.86
PubTator score by year