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Tbio
SRF
Serum response factor

Protein Summary
Description
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required for cardiac differentiation and maturation. This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265354
  • ENSP00000265354
  • ENSG00000112658

Symbol
  • MCM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
kinase
0.99
molecular function
0.98
transcription factor binding site profile
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 928.37   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 617   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 928.37   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 617   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 88
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serum response factor
VGNC:12703
462709
Macaque
serum response factor
698861
Mouse
MGI:106658
20807
Rat
RGD:1559787
501099
Dog
serum response factor
VGNC:46799
612861
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serum response factor
Macaque
serum response factor
Mouse
Rat
Dog
serum response factor
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11831-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (184)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Reactome
Extra-nuclear estrogen signaling
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Formins
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Extra-nuclear estrogen signaling
RHO GTPase Effectors
RHO GTPases Activate Formins
Gene Ontology Terms (92)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (205)
1 – 10 of 205
MRTFA
Tbio
Novelty: 0.00270155
Score: 0.994
Data Source: Reactome,STRINGDB
MYOCD
Tbio
Novelty: 0.00354211
Score: 0.994
Data Source: STRINGDB
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.986
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.98
Data Source: STRINGDB
HDAC4
Tclin
Family: Epigenetic
Novelty: 0.00217749
Score: 0.979
Data Source: STRINGDB
ELK1
Tbio
Family: TF
Novelty: 0.21670414
Score: 0.976
Data Source: Reactome,STRINGDB
HOPX
Tbio
Family: TF
Novelty: 0.00415501
Score: 0.975
Data Source: STRINGDB
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
Score: 0.97
Data Source: STRINGDB
ELK4
Tbio
Family: TF
Novelty: 0.03211949
Score: 0.966
Data Source: STRINGDB
MAPKAPK2
Tchem
Family: Kinase
Novelty: 0.00486452
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  928.37

PubMed score by year
PubTator Score  692.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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