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Tbio
PSKH1
Serine/threonine-protein kinase H1

Protein Summary
Description
May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291041
  • ENSP00000291041
  • ENSG00000159792
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
protein domain
0.85
tissue sample
0.7
histone modification site profile
0.63
cellular component
0.61


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.79   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.79   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
6
4
7
97.5
apolipoprotein A 1 measurement
1
1
1
67.6
sleep duration
1
1
1
58.2
hemoglobin measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
97.5
apolipoprotein A 1 measurement
1
67.6
sleep duration
1
58.2
hemoglobin measurement
1
48.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein serine kinase H1
VGNC:13782
468116
Macaque
protein serine kinase H1
700845
Mouse
MGI:3528383
244631
Dog
protein serine kinase H1
VGNC:45088
100687571
Horse
protein serine kinase H1
VGNC:21932
100053657
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein serine kinase H1
Macaque
protein serine kinase H1
Mouse
Dog
protein serine kinase H1
Horse
protein serine kinase H1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P11801-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (22)
1 – 10 of 22
UNC119
Tchem
Novelty: 0.00396292
p_int: 0.997285752
p_ni: 1.4e-7
p_wrong: 0.002714108
Score: 0.319
Data Source: BioPlex,STRINGDB
EFCAB2
Tdark
Novelty: 0.26420728
Score: 0.776
Data Source: STRINGDB
LCAT
Tbio
Family: Enzyme
Novelty: 0.00307544
Score: 0.764
Data Source: STRINGDB
SLC12A4
Tbio
Family: Transporter
Novelty: 0.01077688
Score: 0.764
Data Source: STRINGDB
PSMB10
Tchem
Family: Enzyme
Novelty: 0.00567
Score: 0.753
Data Source: STRINGDB
SLC12A2
Tclin
Family: Transporter
Novelty: 0.0012043
Score: 0.744
Data Source: STRINGDB
SLC12A3
Tclin
Family: Transporter
Novelty: 0.00199394
Score: 0.64
Data Source: STRINGDB
CMPK1
Tbio
Family: Kinase
Novelty: 0.01478492
Score: 0.632
Data Source: STRINGDB
TSTD2
Tdark
Family: Enzyme
Novelty: 1.81982307
Score: 0.573
Data Source: STRINGDB
PPEF2
Tbio
Family: Enzyme
Novelty: 0.18717195
Score: 0.515
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.79

PubMed score by year
PubTator Score  4.99

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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