Tchem ADH5 Alcohol dehydrogenase class-3

Protein Summary

Description

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P11766
• Q6FHR2

Gene Name

• ADH5

Ensembl ID

• ENST00000296412
• ENSP00000296412
• ENSG00000197894

Symbol

• ADHX
• FDH
• FDH
• ADHX
• ADH-3
• FALDH
• GSNOR
• GSH-FDH
• HEL-S-60p

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
disease perturbation	0.95
protein domain	0.92
molecular function	0.91
transcription factor perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Alcohol Dehydrogenase Class-3

Protein / Oxidoreductase / Dehydrogenase / Alcohol Dehydrogenase Class-3

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Alcohol Dehydrogenase Class-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.49   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 380   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 517.49   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0