IGF2R
Cation-independent mannose-6-phosphate receptor
Protein Summary
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene ...more
- ENST00000356956
- ENSP00000349437
- ENSG00000197081
- ENST00000647592
- ENSP00000497964
- MPRI
- MPR1
- MPRI
- CD222
- CIMPR
- M6P-R
- MPR300
- CI-M6PR
- MPR 300
- M6P/IGF2R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
disease perturbation | 0.97 | ||
cellular component | 0.94 | ||
virus perturbation | 0.94 | ||
interacting protein | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 722.41 (req: < 5)
Gene RIFs: 115 (req: <= 3)
Antibodies: 642 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 722.41 (req: >= 5)
Gene RIFs: 115 (req: > 3)
Antibodies: 642 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (330)
Nearest Tclin Targets
Pathways (16)
Reactome (11)
KEGG (2)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Golgi Associated Vesicle Biogenesis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Golgi Associated Vesicle Biogenesis | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (46)
Functions (11)
Components (22)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 5 | 16 | 23 | 2.3 | 98.8 | ||||
glomerular filtration rate | 3 | 5 | 6 | 98.6 | |||||
apolipoprotein B measurement | 2 | 13 | 14 | 98.5 | |||||
total cholesterol measurement | 6 | 15 | 21 | 2.4 | 98.5 | ||||
IGF-1 measurement | 1 | 6 | 6 | 92.7 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 23 | 2.3 | 98.8 | ||||
glomerular filtration rate | 6 | 98.6 | |||||
apolipoprotein B measurement | 14 | 98.5 | |||||
total cholesterol measurement | 21 | 2.4 | 98.5 | ||||
IGF-1 measurement | 6 | 92.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | insulin like growth factor 2 receptor | VGNC:3256 | 463112 | |||||
Macaque | insulin like growth factor 2 receptor | 703220 | ||||||
Mouse | MGI:96435 | 16004 | ||||||
Rat | RGD:2871 | 25151 | ||||||
Dog | insulin like growth factor 2 receptor | VGNC:41901 | 484067 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | insulin like growth factor 2 receptor | |||||
Macaque | insulin like growth factor 2 receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | insulin like growth factor 2 receptor | |||||
Publication Statistics
PubMed Score 722.41
PubMed score by year
PubTator Score 380.18
PubTator score by year
Related Publications
Text Mined References (181)
GeneRif Annotations (115)
Items per page:
0 of 0
PMID | Year | Title |
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