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Tchem
CYP2C9
Cytochrome P450 2C9

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide sugges ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260682
  • ENSP00000260682
  • ENSG00000138109
  • ENST00000461906
  • ENSP00000495649

Symbol
  • CYP2C10
  • CPC9
  • CYP2C
  • CYP2C10
  • CYPIIC9
  • P450IIC9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
drug
1
disease
0.91
molecular function
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2526.33   (req: < 5)
Gene RIFs: 485   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2526.33   (req: >= 5)
Gene RIFs: 485   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
80.2
blood metabolite measurement
1
1
1
79.8
serum metabolite measurement
1
1
1
75.5
response to anticoagulant
1
1
0
6.2
27.2
hormone measurement
1
1
1
4.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
80.2
blood metabolite measurement
1
79.8
serum metabolite measurement
1
75.5
response to anticoagulant
0
6.2
27.2
hormone measurement
1
4.9
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (45)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of maresin-like SPMs
Reactome
Biosynthesis of maresins
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Biosynthesis of DHA-derived SPMs
Biosynthesis of maresin-like SPMs
Biosynthesis of maresins
Gene Ontology Terms (28)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (163)
1 – 10 of 163
CYP2C19
Tchem
Novelty: 0.000394
p_int: 1
Score: 0.977
Data Source: BioPlex,STRINGDB
CYP2C18
Tchem
Novelty: 0.00210821
p_int: 1
Score: 0.571
Data Source: BioPlex,STRINGDB
ADGRE5
Tbio
Family: GPCR
Novelty: 0.01137558
p_int: 0.979795
p_ni: 0.020204867
p_wrong: 1.33e-7
Score: 0.181
Data Source: BioPlex,STRINGDB
TOMM40
Tbio
Novelty: 0.0041507
p_int: 0.869746857
p_ni: 0.130253143
Score: 0.335
Data Source: BioPlex,STRINGDB
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00015515
Score: 0.97
Data Source: STRINGDB
EPHX1
Tchem
Family: Enzyme
Novelty: 0.00220169
Score: 0.969
Data Source: STRINGDB
FMO3
Tbio
Family: Enzyme
Novelty: 0.00567911
Score: 0.954
Data Source: STRINGDB
PPIG
Tchem
Family: Enzyme
Novelty: 0.00014569
Score: 0.952
Data Source: STRINGDB
EPHX2
Tchem
Family: Enzyme
Novelty: 0.00430741
Score: 0.951
Data Source: STRINGDB
CYP4F2
Tchem
Family: Enzyme
Novelty: 0.0050361
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  2526.33

PubMed score by year
PubTator Score  1974.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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