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Tbio
SFTPC
Pulmonary surfactant-associated protein C

Protein Summary
Description
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript v ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318561
  • ENSP00000316152
  • ENSG00000168484

Symbol
  • SFTP2
  • SP-C
  • PSP-C
  • SFTP2
  • SMDP2
  • BRICD6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.78
disease
0.61
biological process
0.58
protein domain
0.58
disease perturbation
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 636.44   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 401   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 636.44   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 401   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
surfactant protein C
VGNC:799
464041
Macaque
surfactant protein C
707696
Mouse
MGI:109517
20389
Rat
RGD:3666
50683
Dog
surfactant protein C
477385
Species
Name
OMA
EggNOG
Inparanoid
Chimp
surfactant protein C
Macaque
surfactant protein C
Mouse
Rat
Dog
surfactant protein C
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11686-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) (R-HSA-5688890)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Reactome
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
Reactome
Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)
Reactome
Disease
Reactome
Diseases associated with surfactant metabolism
Name
Explore in Pharos
Explore in Source
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)
Disease
Diseases associated with surfactant metabolism
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (80)
1 – 10 of 80
NPTXR
Tbio
Novelty: 0.00727951
p_int: 0.999982197
p_ni: 5.6e-8
p_wrong: 0.000017746
Score: 0.193
Data Source: BioPlex,STRINGDB
CBX8
Tchem
Family: Epigenetic
Novelty: 0.00205993
p_int: 0.999977858
p_ni: 0.000022142
Score: 0.219
Data Source: BioPlex,STRINGDB
CBX6
Tchem
Family: Epigenetic
Novelty: 0.08868575
p_int: 0.999817411
p_ni: 0.000182589
Score: 0.169
Data Source: BioPlex,STRINGDB
SCARF2
Tbio
Novelty: 0.08833851
p_int: 0.999653495
p_ni: 0.000346505
Score: 0.219
Data Source: BioPlex,STRINGDB
PHC2
Tbio
Novelty: 0.01943349
p_int: 0.993378609
p_ni: 0.006621314
p_wrong: 7.7e-8
Score: 0.241
Data Source: BioPlex,STRINGDB
BMI1
Tbio
Novelty: 0.00158043
p_int: 0.98512419
p_ni: 0.01487581
Score: 0.222
Data Source: BioPlex,STRINGDB
SCARB1
Tchem
Novelty: 0.00087703
p_int: 0.967174807
p_ni: 0.032825193
Score: 0.197
Data Source: BioPlex,STRINGDB
MFAP3
Tdark
Novelty: 0.55512255
p_int: 0.952926252
p_ni: 0.047072858
p_wrong: 8.89e-7
Data Source: BioPlex
MPZL1
Tbio
Novelty: 0.03292508
p_int: 0.846938969
p_ni: 0.153060925
p_wrong: 1.06e-7
Data Source: BioPlex
EIF2AK3
Tchem
Family: Kinase
Novelty: 0.00044559
p_int: 0.832667252
p_ni: 0.16432636
p_wrong: 0.003006388
Score: 0.2
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  636.44

PubMed score by year
PubTator Score  499.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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