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Tbio
EPX
Eosinophil peroxidase

Protein Summary
Description
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225371
  • ENSP00000225371
  • ENSG00000121053

Symbol
  • EPER
  • EPO
  • EPP
  • EPO
  • EPP
  • EPXD
  • EPX-PEN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.59
chemical
0.52
gene perturbation
0.49
molecular function
0.49
cell type or tissue
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.11   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.11   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (53)
1 – 10 of 53
TMEM237
Tdark
Novelty: 0.27005874
p_int: 0.999991588
p_ni: 4.1e-8
p_wrong: 0.00000837
Score: 0.622
Data Source: BioPlex,STRINGDB
RNASE3
Tbio
Family: Enzyme
Novelty: 0.00059878
Score: 0.906
Data Source: STRINGDB
RNASE2
Tchem
Family: Enzyme
Novelty: 0.00267471
Score: 0.901
Data Source: STRINGDB
PRG2
Tbio
Novelty: 0.00548995
Score: 0.742
Data Source: STRINGDB
IL5
Tclin
Novelty: 0.0001684
Score: 0.726
Data Source: STRINGDB
RNASE6
Tbio
Family: Enzyme
Novelty: 0.06300793
Score: 0.699
Data Source: STRINGDB
APELA
Tbio
Novelty: 0.01002099
Score: 0.669
Data Source: STRINGDB
CCL11
Tbio
Novelty: 0.00086805
Score: 0.669
Data Source: STRINGDB
GADD45GIP1
Tbio
Novelty: 0.03765684
Score: 0.668
Data Source: STRINGDB
FCER1A
Tbio
Novelty: 0.00362182
Score: 0.665
Data Source: STRINGDB
Publication Statistics
PubMed Score  259.11

PubMed score by year
PubTator Score  392.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer