Protein Summary
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]
- ENST00000225371
- ENSP00000225371
- ENSG00000121053
- EPER
- EPO
- EPP
- EPO
- EPP
- EPXD
- EPX-PEN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.59 | ||
chemical | 0.52 | ||
gene perturbation | 0.49 | ||
molecular function | 0.49 | ||
cell type or tissue | 0.46 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 257.64 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 355 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 257.64 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 355 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (53)
TMEM237
Novelty: 0.27005874
p_int: 0.999991588
p_ni: 4.1e-8
p_wrong: 0.00000837
Score: 0.622
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (3)
Components (5)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 5 | 6 | 98.1 | |||||
myeloperoxidase measurement | 2 | 3 | 3 | 95.8 | |||||
basophil count | 2 | 3 | 4 | 92.7 | |||||
neutrophil percentage of leukocytes | 2 | 3 | 4 | 91.4 | |||||
basophil percentage of leukocytes | 1 | 3 | 3 | 91.4 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 6 | 98.1 | |||||
myeloperoxidase measurement | 3 | 95.8 | |||||
basophil count | 4 | 92.7 | |||||
neutrophil percentage of leukocytes | 4 | 91.4 | |||||
basophil percentage of leukocytes | 3 | 91.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | eosinophil peroxidase | VGNC:9275 | 468420 | |||||
Macaque | eosinophil peroxidase | 709655 | ||||||
Mouse | MGI:107569 | 13861 | ||||||
Rat | RGD:1311882 | 303414 | ||||||
Horse | eosinophil peroxidase | VGNC:17642 | 100070907 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | eosinophil peroxidase | |||||
Macaque | eosinophil peroxidase | |||||
Mouse | ||||||
Rat | ||||||
Horse | eosinophil peroxidase | |||||
Publication Statistics
PubMed Score 257.64
PubMed score by year
PubTator Score 392.91
PubTator score by year
Related Publications
Text Mined References (37)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
|---|