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Tchem
CETP
Cholesteryl ester transfer protein

Protein Summary
Description
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796). The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000200676
  • ENSP00000200676
  • ENSG00000087237
  • ENST00000379780
  • ENSP00000369106

Symbol
  • BPIFF
  • HDLCQ10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
biological term
0.99
disease
0.87
trait
0.86
molecular function
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2115.18   (req: < 5)
Gene RIFs: 409   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2115.18   (req: >= 5)
Gene RIFs: 409   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 820
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
16
24
51
5.7
99.8
total cholesterol measurement
6
10
16
6.1
99.3
cholesteryl ester transfer protein measurement
1
2
2
99
2
2
0
1.4
94.1
3
2
0
1.2
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
51
5.7
99.8
total cholesterol measurement
16
6.1
99.3
cholesteryl ester transfer protein measurement
2
99
0
1.4
94.1
0
1.2
92.6
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholesteryl ester transfer protein
VGNC:9022
467982
Macaque
cholesteryl ester transfer protein
710267
Opossum
cholesteryl ester transfer protein
100021113
Platypus
cholesteryl ester transfer protein [Source:HGNC Symbol;Acc:HGNC:1869]
Chicken
cholesteryl ester transfer protein
CGNC:841
415645
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholesteryl ester transfer protein
Macaque
cholesteryl ester transfer protein
Opossum
cholesteryl ester transfer protein
Platypus
cholesteryl ester transfer protein [Source:HGNC Symbol;Acc:HGNC:1869]
Chicken
cholesteryl ester transfer protein
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11597-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
HDL remodeling (R-HSA-8964058)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HDL remodeling
Reactome
LDL remodeling
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
HDL remodeling
LDL remodeling
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Gene Ontology Terms (29)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (99)
1 – 10 of 99
APOA1
Tbio
Novelty: 0.0001216
Score: 0.989
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.989
Data Source: STRINGDB
APOF
Tbio
Novelty: 0.02636736
Score: 0.979
Data Source: STRINGDB
LCAT
Tbio
Family: Enzyme
Novelty: 0.00307544
Score: 0.972
Data Source: STRINGDB
LPA
Tbio
Family: Enzyme
Novelty: 0.00054858
Score: 0.96
Data Source: STRINGDB
APOE
Tbio
Novelty: 0.00005049
Score: 0.942
Data Source: STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.938
Data Source: STRINGDB
APOC3
Tclin
Novelty: 0.0009635
Score: 0.938
Data Source: STRINGDB
APOC1
Tbio
Novelty: 0.00338935
Score: 0.932
Data Source: STRINGDB
LIPC
Tchem
Family: Enzyme
Novelty: 0.00219107
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  2115.18

PubMed score by year
PubTator Score  1568.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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