Tchem CETP Cholesteryl ester transfer protein

Protein Summary

Description

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796). The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• P11597
• Q13987
• Q13988
• Q53YZ1

Gene Name

• CETP

Ensembl ID

• ENST00000200676
• ENSP00000200676
• ENSG00000087237
• ENST00000379780
• ENSP00000369106

Symbol

• BPIFF
• HDLCQ10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
biological term	0.99
disease	0.87
trait	0.86
molecular function	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2247.11   (req: < 5)

Gene RIFs: 476   (req: <= 3)

Antibodies: 342   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2247.11   (req: >= 5)

Gene RIFs: 476   (req: > 3)

Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 901

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0