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Tclin
DMD
Dystrophin

Protein Summary
Description
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361471
  • ENSP00000354464
  • ENSG00000198947
  • ENST00000378680
  • ENSP00000367951
  • ENST00000378702
  • ENSP00000367974
  • ENST00000378723
  • ENSP00000367997

Symbol
  • BMD
  • CMD3B
  • MRX85
  • DXS142
  • DXS164
  • DXS206
  • DXS230
  • DXS239
  • DXS268
  • DXS269
  • DXS270
  • DXS272
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
biological term
0.99
co-expressed gene
0.96
biological process
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3953.06   (req: < 5)
Gene RIFs: 265   (req: <= 3)
Antibodies: 486   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3953.06   (req: >= 5)
Gene RIFs: 265   (req: > 3)
Antibodies: 486   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (258)
SNTG2
Tbio
Novelty:  0.04056715
p_int:  1
Score:  0.989
Data Source:  BioPlex,STRINGDB
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.999999999
p_ni:  1e-9
Score:  0.958
Data Source:  BioPlex,STRINGDB
DTNA
Tbio
Novelty:  0.01165754
p_int:  0.999999995
p_ni:  5e-9
Score:  0.738
Data Source:  BioPlex,STRINGDB
CTNNAL1
Tbio
Novelty:  0.03667606
p_int:  0.999999994
p_ni:  1e-9
p_wrong:  6e-9
Score:  0.789
Data Source:  BioPlex,STRINGDB
SNTA1
Tbio
Novelty:  0.01668288
p_int:  0.999999988
p_ni:  9e-9
p_wrong:  3e-9
Score:  0.982
Data Source:  BioPlex,STRINGDB
SNTB1
Tbio
Novelty:  0.05324344
p_int:  0.999999952
p_ni:  2e-9
p_wrong:  4.6e-8
Score:  0.987
Data Source:  BioPlex,STRINGDB
DTNB
Tbio
Novelty:  0.0586565
p_int:  0.999999787
p_ni:  2.11e-7
p_wrong:  2e-9
Score:  0.791
Data Source:  BioPlex,STRINGDB
SNTB2
Tbio
Novelty:  0.05469501
p_int:  0.999999746
p_ni:  2.51e-7
p_wrong:  3e-9
Score:  0.962
Data Source:  BioPlex,STRINGDB
LONRF3
Tdark
Family:  Enzyme
Novelty:  1.01853217
p_int:  0.999980955
p_ni:  2.75e-7
p_wrong:  0.00001877
Score:  0.259
Data Source:  BioPlex,STRINGDB
HAUS4
Tbio
Novelty:  0.91427982
p_int:  0.999967885
p_ni:  0.000032115
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Muscle contraction
Reactome
Non-integrin membrane-ECM interactions
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Muscle contraction
Non-integrin membrane-ECM interactions
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (50)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
2
1
0
12.8
60.2
body mass index
1
1
1
24.5
1
1
0
1.8
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
0
12.8
60.2
body mass index
1
24.5
0
1.8
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
dystrophin-like
707966
Mouse
MGI:94909
13405
Rat
RGD:2507
24907
Dog
dystrophin
VGNC:54134
606758
Platypus
dystrophin
100075838
Species
Name
OMA
EggNOG
Inparanoid
Macaque
dystrophin-like
Mouse
Rat
Dog
dystrophin
Platypus
dystrophin
Publication Statistics
PubMed Score 3953.06
PubMed score by year
PubTator Score 3076.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title