CYP19A1
Aromatase
Protein Summary
Catalyzes the formation of aromatic C18 estrogens from C19 androgens. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
- ENST00000396402
- ENSP00000379683
- ENSG00000137869
- ENST00000396404
- ENSP00000379685
- ENST00000405913
- ENSP00000383930
- ENST00000557858
- ENSP00000452627
- ENST00000559878
- ENSP00000453149
- ARO1
- CYAR
- CYP19
- ARO
- ARO1
- CPV1
- CYAR
- CYP19
- CYPXIX
- P-450AROM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
drug | 1 | ||
hub protein | 0.95 | ||
disease | 0.87 | ||
phenotype | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3663.71 (req: < 5)
Gene RIFs: 640 (req: <= 3)
Antibodies: 603 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3663.71 (req: >= 5)
Gene RIFs: 640 (req: > 3)
Antibodies: 603 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1226
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 15