Protein Classes
Protein Summary
Catalyzes the formation of aromatic C18 estrogens from C19 androgens. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
- ENST00000396402
- ENSP00000379683
- ENSG00000137869
- ENST00000396404
- ENSP00000379685
- ENST00000405913
- ENSP00000383930
- ENST00000557858
- ENSP00000452627
- ENST00000559878
- ENSP00000453149
- ARO1
- CYAR
- CYP19
- ARO
- ARO1
- CPV1
- CYAR
- CYP19
- CYPXIX
- P-450AROM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
drug | 1 | ||
hub protein | 0.95 | ||
disease | 0.87 | ||
phenotype | 0.74 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2977.77 (req: < 5)
Gene RIFs: 554 (req: <= 3)
Antibodies: 603 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2977.77 (req: >= 5)
Gene RIFs: 554 (req: > 3)
Antibodies: 603 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1123
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 14
Approved Drugs (14)
1 – 10 of 14
Active Ligands (1123)
1 – 10 of 1123
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
estradiol measurement | 4 | 8 | 9 | 1.4 | 99.6 | ||||
testosterone measurement | 4 | 4 | 5 | 99.1 | |||||
heel bone mineral density | 3 | 5 | 9 | 97.9 | |||||
sex hormone-binding globulin measurement | 2 | 3 | 3 | 96.7 | |||||
body height | 6 | 5 | 7 | 95.7 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
estradiol measurement | 9 | 1.4 | 99.6 | ||||
testosterone measurement | 5 | 99.1 | |||||
heel bone mineral density | 9 | 97.9 | |||||
sex hormone-binding globulin measurement | 3 | 96.7 | |||||
body height | 7 | 95.7 | |||||
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (25)
Reactome (13)
KEGG (3)
PathwayCommons (2)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Defective CYP19A1 causes Aromatase excess syndrome (AEXS) | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Defective CYP19A1 causes Aromatase excess syndrome (AEXS) | ||||
Disease | ||||
Diseases of metabolism | ||||
Gene Ontology Terms (23)
Functions (7)
Components (3)
Processes (13)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (189)
1 – 10 of 189
RC3H2
Novelty: 0.10893793
p_int: 0.999044367
p_ni: 0.000955628
p_wrong: 5e-9
Score: 0.282
Data Source: BioPlex,STRINGDB
CD109
Novelty: 0.01280272
p_int: 0.987692325
p_ni: 0.012307675
p_wrong: 1e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
H2AFX
Novelty: 0.00048694
p_int: 0.976403966
p_ni: 0.001385213
p_wrong: 0.022210821
Score: 0.277
Data Source: BioPlex,STRINGDB
CACNA2D1
Family: IC
Novelty: 0.01744541
p_int: 0.84664715
p_ni: 0.153352792
p_wrong: 5.8e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
NPLOC4
Novelty: 0.01690434
p_int: 0.831892851
p_ni: 0.168107149
Score: 0.241
Data Source: BioPlex,STRINGDB
HSD17B6
Family: Enzyme
Novelty: 0.01428594
Score: 0.986
Data Source: STRINGDB
HSD3B1
Family: Enzyme
Novelty: 0.0019271
Score: 0.986
Data Source: STRINGDB
HSD17B1
Family: Enzyme
Novelty: 0.00313425
Score: 0.984
Data Source: STRINGDB
HSD3B2
Family: Enzyme
Novelty: 0.00711552
Score: 0.973
Data Source: STRINGDB
SRD5A1
Family: Enzyme
Novelty: 0.00987219
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score 2977.77
PubMed score by year
PubTator Score 2002.36
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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