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Tclin
CYP19A1
Aromatase

Protein Summary
Description
Catalyzes the formation of aromatic C18 estrogens from C19 androgens. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396402
  • ENSP00000379683
  • ENSG00000137869
  • ENST00000396404
  • ENSP00000379685
  • ENST00000405913
  • ENSP00000383930
  • ENST00000557858
  • ENSP00000452627
  • ENST00000559878
  • ENSP00000453149

Symbol
  • ARO1
  • CYAR
  • CYP19
  • ARO
  • ARO1
  • CPV1
  • CYAR
  • CYP19
  • CYPXIX
  • P-450AROM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
hub protein
0.95
disease
0.87
phenotype
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2977.77   (req: < 5)
Gene RIFs: 554   (req: <= 3)
Antibodies: 603   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2977.77   (req: >= 5)
Gene RIFs: 554   (req: > 3)
Antibodies: 603   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1123
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14
Approved Drugs (14)
1 – 10 of 14
fadrozole
chemical structure image
androstanolone
chemical structure image
letrozole
chemical structure image
osilodrostat
chemical structure image
clotrimazole
chemical structure image
testosterone
chemical structure image
quercetin
chemical structure image
anastrozole
chemical structure image
androstenedione
chemical structure image
miconazole
chemical structure image
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
estradiol measurement
4
8
9
1.4
99.6
testosterone measurement
4
4
5
99.1
heel bone mineral density
3
5
9
97.9
sex hormone-binding globulin measurement
2
3
3
96.7
body height
6
5
7
95.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
estradiol measurement
9
1.4
99.6
testosterone measurement
5
99.1
heel bone mineral density
9
97.9
sex hormone-binding globulin measurement
3
96.7
body height
7
95.7
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Reactome
Disease
Reactome
Diseases of metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Disease
Diseases of metabolism
Gene Ontology Terms (23)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (189)
1 – 10 of 189
RC3H2
Tbio
Novelty: 0.10893793
p_int: 0.999044367
p_ni: 0.000955628
p_wrong: 5e-9
Score: 0.282
Data Source: BioPlex,STRINGDB
CD109
Tbio
Novelty: 0.01280272
p_int: 0.987692325
p_ni: 0.012307675
p_wrong: 1e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.976403966
p_ni: 0.001385213
p_wrong: 0.022210821
Score: 0.277
Data Source: BioPlex,STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.01744541
p_int: 0.84664715
p_ni: 0.153352792
p_wrong: 5.8e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
NPLOC4
Tbio
Novelty: 0.01690434
p_int: 0.831892851
p_ni: 0.168107149
Score: 0.241
Data Source: BioPlex,STRINGDB
HSD17B6
Tbio
Family: Enzyme
Novelty: 0.01428594
Score: 0.986
Data Source: STRINGDB
HSD3B1
Tchem
Family: Enzyme
Novelty: 0.0019271
Score: 0.986
Data Source: STRINGDB
HSD17B1
Tchem
Family: Enzyme
Novelty: 0.00313425
Score: 0.984
Data Source: STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
Score: 0.973
Data Source: STRINGDB
SRD5A1
Tclin
Family: Enzyme
Novelty: 0.00987219
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score  2977.77

PubMed score by year
PubTator Score  2002.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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