Protein Summary
Catalyzes the formation of aromatic C18 estrogens from C19 androgens. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
- ENST00000396402
- ENSP00000379683
- ENSG00000137869
- ENST00000396404
- ENSP00000379685
- ENST00000405913
- ENSP00000383930
- ENST00000557858
- ENSP00000452627
- ENST00000559878
- ENSP00000453149
- ARO1
- CYAR
- CYP19
- ARO
- ARO1
- CPV1
- CYAR
- CYP19
- CYPXIX
- P-450AROM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
drug | 1 | ||
hub protein | 0.95 | ||
disease | 0.87 | ||
phenotype | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3032.08 (req: < 5)
Gene RIFs: 554 (req: <= 3)
Antibodies: 603 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3032.08 (req: >= 5)
Gene RIFs: 554 (req: > 3)
Antibodies: 603 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1214
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 15
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (15)
Active Ligands (1214)
Protein-Protein Interactions (189)
RC3H2
Novelty: 0.10893793
p_int: 0.999044367
p_ni: 0.000955628
p_wrong: 5e-9
Score: 0.282
Data Source: BioPlex,STRINGDB
CD109
Novelty: 0.01280272
p_int: 0.987692325
p_ni: 0.012307675
p_wrong: 1e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
H2AFX
Novelty: 0.00048694
p_int: 0.976403966
p_ni: 0.001385213
p_wrong: 0.022210821
Score: 0.277
Data Source: BioPlex,STRINGDB
CACNA2D1
Family: IC
Novelty: 0.01744541
p_int: 0.84664715
p_ni: 0.153352792
p_wrong: 5.8e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
NPLOC4
Novelty: 0.01690434
p_int: 0.831892851
p_ni: 0.168107149
Score: 0.241
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (25)
Reactome (13)
KEGG (3)
PathwayCommons (2)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Defective CYP19A1 causes Aromatase excess syndrome (AEXS) | ||||
Reactome | Disease | ||||
Reactome | Diseases of metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Defective CYP19A1 causes Aromatase excess syndrome (AEXS) | ||||
Disease | ||||
Diseases of metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (7)
Components (3)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
estradiol measurement | 4 | 8 | 9 | 1.4 | 98.8 | ||||
heel bone mineral density | 3 | 7 | 11 | 98.8 | |||||
body height | 7 | 7 | 9 | 97.5 | |||||
testosterone measurement | 4 | 4 | 5 | 95.9 | |||||
sex hormone-binding globulin measurement | 2 | 3 | 3 | 92.8 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
estradiol measurement | 9 | 1.4 | 98.8 | ||||
heel bone mineral density | 11 | 98.8 | |||||
body height | 9 | 97.5 | |||||
testosterone measurement | 5 | 95.9 | |||||
sex hormone-binding globulin measurement | 3 | 92.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | cytochrome P450, family 19, subfamily A, polypeptide 1 | 678697 | ||||||
Mouse | MGI:88587 | 13075 | ||||||
Rat | RGD:2457 | 25147 | ||||||
Dog | cytochrome P450 family 19 subfamily A member 1 | VGNC:50331 | 494003 | |||||
Horse | cytochrome P450 family 19 subfamily A member 1 | VGNC:50557 | 100009712 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | cytochrome P450, family 19, subfamily A, polypeptide 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 family 19 subfamily A member 1 | |||||
Horse | cytochrome P450 family 19 subfamily A member 1 | |||||
Publication Statistics
PubMed Score 3032.08
PubMed score by year
PubTator Score 2002.36
PubTator score by year
Related Publications
Text Mined References (722)
GeneRif Annotations (554)
Items per page:
0 of 0
PMID | Year | Title |
|---|