Protein Summary
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity. This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cyt ...more
- ENST00000301141
- ENSP00000301141
- ENSG00000255974
- CYP2A3
- CPA6
- CYP2A
- CYP2A3
- P450PB
- CYPIIA6
- P450C2A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
chemical | 0.99 | ||
biological term | 0.91 | ||
co-expressed gene | 0.82 | ||
molecular function | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1021.54 (req: < 5)
Gene RIFs: 190 (req: <= 3)
Antibodies: 407 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1021.54 (req: >= 5)
Gene RIFs: 190 (req: > 3)
Antibodies: 407 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 106
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (106)
Protein-Protein Interactions (114)
RABAC1
Novelty: 0.01749453
p_int: 0.761078473
p_ni: 0.00043792
p_wrong: 0.238483607
Score: 0.544
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (13)
Upstream (6)
Downstream (7)
1 – 5 of 6
Pathways (59)
Reactome (6)
KEGG (7)
PathwayCommons (2)
WikiPathways (44)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | CYP2E1 reactions | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Metabolism | ||||
Reactome | Phase I - Functionalization of compounds | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
CYP2E1 reactions | ||||
Cytochrome P450 - arranged by substrate type | ||||
Metabolism | ||||
Phase I - Functionalization of compounds | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (7)
Components (5)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
nicotine metabolite ratio | 3 | 15 | 16 | 99.8 | |||||
cigarettes per day measurement | 9 | 10 | 16 | 99.3 | |||||
hematocrit | 3 | 7 | 9 | 98.6 | |||||
hemoglobin measurement | 3 | 6 | 9 | 98.3 | |||||
alkaline phosphatase measurement | 2 | 4 | 3 | 11.2 | 97.5 | ||||
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
nicotine metabolite ratio | 16 | 99.8 | |||||
cigarettes per day measurement | 16 | 99.3 | |||||
hematocrit | 9 | 98.6 | |||||
hemoglobin measurement | 9 | 98.3 | |||||
alkaline phosphatase measurement | 3 | 11.2 | 97.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | cytochrome P450, family 2, subfamily A, polypeptide 23 precursor [Source:RefSeq peptide;Acc:NP_001035306] | |||||||
Mouse | MGI:88596 | 13086 | ||||||
Horse | cytochrome P450 2A13 | 100146413 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | cytochrome P450, family 2, subfamily A, polypeptide 23 precursor [Source:RefSeq peptide;Acc:NP_001035306] | |||||
Mouse | ||||||
Horse | cytochrome P450 2A13 | |||||
Publication Statistics
PubMed Score 1021.54
PubMed score by year
PubTator Score 660.53
PubTator score by year
Related Publications
Text Mined References (281)
GeneRif Annotations (190)
Items per page:
0 of 0
PMID | Year | Title |
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