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Tchem
CYP2A6
Cytochrome P450 2A6

Protein Summary
Description
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity. This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cyt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301141
  • ENSP00000301141
  • ENSG00000255974

Symbol
  • CYP2A3
  • CPA6
  • CYP2A
  • CYP2A3
  • P450PB
  • CYPIIA6
  • P450C2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
chemical
0.99
biological term
0.91
co-expressed gene
0.82
molecular function
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1004.82   (req: < 5)
View Publications
Gene RIFs: 190   (req: <= 3)
View Gene RIFs
Antibodies: 407   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1004.82   (req: >= 5)
Gene RIFs: 190   (req: > 3)
Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
EFO_0006525
3
3
5
99.4
smoking cessation
EFO_0004319
2
1
2
96.9
nicotine metabolite ratio
EFO_0007794
2
1
2
95
smoking behavior
EFO_0004318
1
1
1
90
caffeine metabolite measurement
EFO_0007872
1
3
0
6.5
86.1
Items per page:
1 – 5 of 19
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
EFO_0006525
5
99.4
smoking cessation
EFO_0004319
2
96.9
nicotine metabolite ratio
EFO_0007794
2
95
smoking behavior
EFO_0004318
1
90
caffeine metabolite measurement
EFO_0007872
0
6.5
86.1
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cytochrome P450, family 2, subfamily A, polypeptide 23 precursor [Source:RefSeq peptide;Acc:NP_001035306]
Mouse
cytochrome P450, family 2, subfamily a, polypeptide 4
MGI:88596
13086
Horse
cytochrome P450 2A13
100146413
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cytochrome P450, family 2, subfamily A, polypeptide 23 precursor [Source:RefSeq peptide;Acc:NP_001035306]
Mouse
cytochrome P450, family 2, subfamily a, polypeptide 4
Horse
cytochrome P450 2A13
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (59)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
221 targets
R-HSA-211859
Reactome
CYP2E1 reactions
11 targets
R-HSA-211999
Reactome
Cytochrome P450 - arranged by substrate type
65 targets
R-HSA-211897
Reactome
Metabolism
2112 targets
R-HSA-1430728
Reactome
Phase I - Functionalization of compounds
105 targets
R-HSA-211945
Name
Explore in Pharos
Explore in Source
Biological oxidations
221 targets
R-HSA-211859
CYP2E1 reactions
11 targets
R-HSA-211999
Cytochrome P450 - arranged by substrate type
65 targets
R-HSA-211897
Metabolism
2112 targets
R-HSA-1430728
Phase I - Functionalization of compounds
105 targets
R-HSA-211945
Gene Ontology Terms (21)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
coumarin 7-hydroxylase activity
Inferred from Direct Assay (IDA)
UniProtKB
heme binding
Inferred from Direct Assay (IDA)
UniProtKB
enzyme binding
Inferred from Physical Interaction (IPI)
BHF-UCL
arachidonic acid epoxygenase activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
steroid hydroxylase activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
iron ion binding
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (114)
1 – 10 of 114
CYP2A7
Tbio
Novelty: 0.01218328
p_int: 1
Score: 0.943
Data Source: BioPlex,STRINGDB
RABAC1
Tbio
Novelty: 0.01749453
p_int: 0.761078473
p_ni: 0.00043792
p_wrong: 0.238483607
Score: 0.544
Data Source: BioPlex,STRINGDB
EPHX1
Tchem
Family: Enzyme
Novelty: 0.00220169
Score: 0.96
Data Source: STRINGDB
NAT2
Tbio
Family: Enzyme
Novelty: 0.00150849
Score: 0.955
Data Source: STRINGDB
AOX1
Tbio
Family: Enzyme
Novelty: 0.0025823
Score: 0.954
Data Source: STRINGDB
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00015515
Score: 0.949
Data Source: STRINGDB
DPYD
Tclin
Family: Enzyme
Novelty: 0.00207216
Score: 0.945
Data Source: STRINGDB
CYP4A11
Tbio
Novelty: 0.01121493
Score: 0.944
Data Source: STRINGDB
CYP3A5
Tclin
Family: Enzyme
Novelty: 0.00105607
Score: 0.942
Data Source: STRINGDB
CYP3A7
Tclin
Family: Enzyme
Novelty: 0.00736888
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  1004.82

PubMed score by year
PubTator Score  660.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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