Tbio PC Pyruvate carboxylase, mitochondrial

Protein Summary

Description

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P11498
• B4DN00
• Q16705

Gene Name

• PC

Ensembl ID

• ENST00000393955
• ENSP00000377527
• ENSG00000173599
• ENST00000393958
• ENSP00000377530
• ENST00000393960
• ENSP00000377532

Symbol

• PCB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
histone modification site profile	0.87
transcription factor binding site profile	0.85
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Ligase / Pyruvate Carboxylase, Mitochondrial

DTO Classes

Protein / Enzyme / Ligase / Pyruvate Carboxylase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.22   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 325   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.22   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0