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Tbio
PC
Pyruvate carboxylase, mitochondrial

Protein Classes
Protein Summary
Description
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393955
  • ENSP00000377527
  • ENSG00000173599
  • ENST00000393958
  • ENSP00000377530
  • ENST00000393960
  • ENSP00000377532

Symbol
  • PCB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
histone modification site profile
0.87
transcription factor binding site profile
0.85
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.06   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.06   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
73.1
risk-taking behaviour
1
1
1
22.3
1
1
0
1.1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
73.1
risk-taking behaviour
1
22.3
0
1.1
8.1
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pyruvate carboxylase
713103
Rat
RGD:3262
25104
Dog
pyruvate carboxylase
VGNC:51885
483704
Cow
pyruvate carboxylase
338471
Opossum
pyruvate carboxylase
100015028
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pyruvate carboxylase
Rat
Dog
pyruvate carboxylase
Cow
pyruvate carboxylase
Opossum
pyruvate carboxylase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11498-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Biotin transport and metabolism (R-HSA-196780)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biotin transport and metabolism
Reactome
Defective HLCS causes multiple carboxylase deficiency
Reactome
Defects in biotin (Btn) metabolism
Reactome
Defects in vitamin and cofactor metabolism
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Biotin transport and metabolism
Defective HLCS causes multiple carboxylase deficiency
Defects in biotin (Btn) metabolism
Defects in vitamin and cofactor metabolism
Disease
Protein-Protein Interactions (222)
1 – 10 of 222
STRAP
Tbio
Family: Enzyme
Novelty: 0.0336013
p_int: 0.999971257
p_ni: 0.000028743
Score: 0.156
Data Source: BioPlex,STRINGDB
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.999746337
p_ni: 0.000253663
Data Source: BioPlex
ASS1
Tbio
Family: Enzyme
Novelty: 0.00358761
p_int: 0.999515706
p_ni: 0.000484294
Score: 0.66
Data Source: BioPlex,STRINGDB
LYRM7
Tbio
Novelty: 0.16270565
p_int: 0.999205507
p_ni: 0.000794493
Data Source: BioPlex
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
p_int: 0.983553598
p_ni: 0.016446402
Score: 0.223
Data Source: BioPlex,STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.1114547
p_int: 0.953391939
p_ni: 0.046608061
Data Source: BioPlex
SLAMF1
Tbio
Novelty: 0.00112892
p_int: 0.952224337
p_ni: 0.047775663
Data Source: BioPlex
TMEM87A
Tdark
Novelty: 0.33614983
p_int: 0.939812599
p_ni: 0.060187401
Data Source: BioPlex
C1QTNF9B
Tdark
Novelty: 0.7643008
p_int: 0.927971136
p_ni: 0.072028864
Data Source: BioPlex
CBWD1
Tbio
Novelty: 0.04321511
p_int: 0.915015883
p_ni: 0.084984117
Score: 0.526
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  295.06

PubMed score by year
PubTator Score  3944.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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