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Tbio
PC
Pyruvate carboxylase, mitochondrial

Protein Classes
Protein Summary
Description
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393955
  • ENSP00000377527
  • ENSG00000173599
  • ENST00000393958
  • ENSP00000377530
  • ENST00000393960
  • ENSP00000377532

Symbol
  • PCB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
histone modification site profile
0.87
transcription factor binding site profile
0.85
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.16   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.16   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (33)
Biotin transport and metabolism (R-HSA-196780)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biotin transport and metabolism
Reactome
Defective HLCS causes multiple carboxylase deficiency
Reactome
Defects in biotin (Btn) metabolism
Reactome
Defects in vitamin and cofactor metabolism
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Biotin transport and metabolism
Defective HLCS causes multiple carboxylase deficiency
Defects in biotin (Btn) metabolism
Defects in vitamin and cofactor metabolism
Disease
Protein-Protein Interactions (222)
1 – 10 of 222
STRAP
Tbio
Family: Enzyme
Novelty: 0.03966134
p_int: 0.999971257
p_ni: 0.000028743
Score: 0.156
Data Source: BioPlex,STRINGDB
DEFA5
Tbio
Novelty: 0.01045537
p_int: 0.999746337
p_ni: 0.000253663
Data Source: BioPlex
ASS1
Tbio
Family: Enzyme
Novelty: 0.00451148
p_int: 0.999515706
p_ni: 0.000484294
Score: 0.66
Data Source: BioPlex,STRINGDB
LYRM7
Tbio
Novelty: 0.18759771
p_int: 0.999205507
p_ni: 0.000794493
Data Source: BioPlex
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00875526
p_int: 0.983553598
p_ni: 0.016446402
Score: 0.223
Data Source: BioPlex,STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.13729977
p_int: 0.953391939
p_ni: 0.046608061
Data Source: BioPlex
SLAMF1
Tbio
Novelty: 0.00121506
p_int: 0.952224337
p_ni: 0.047775663
Data Source: BioPlex
TMEM87A
Tdark
Novelty: 2
p_int: 0.939812599
p_ni: 0.060187401
Data Source: BioPlex
C1QTNF9B
Tdark
Novelty: 0.88888889
p_int: 0.927971136
p_ni: 0.072028864
Data Source: BioPlex
CBWD1
Tbio
Novelty: 0.04454343
p_int: 0.915015883
p_ni: 0.084984117
Score: 0.526
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  246.16

PubMed score by year
PubTator Score  3944.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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