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Tbio
GNAT1
Guanine nucleotide-binding protein G(t) subunit alpha-1

Protein Summary
Description
Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity). Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232461
  • ENSP00000232461
  • ENSG00000114349
  • ENST00000433068
  • ENSP00000387555

Symbol
  • GNATR
  • GBT1
  • GNATR
  • CSNB1G
  • CSNBAD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
microRNA
0.93
gene perturbation
0.82
virus perturbation
0.68
biological process
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.49   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.49   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
1
0
6
2.3
reticulocyte measurement
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
0
6
2.3
reticulocyte measurement
1
0.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha transducin 1
VGNC:8835
744813
Mouse
MGI:95778
14685
Rat
RGD:1304683
363143
Dog
G protein subunit alpha transducin 1
VGNC:41307
403613
Horse
G protein subunit alpha transducin 1 [Source:HGNC Symbol;Acc:HGNC:4393]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha transducin 1
Mouse
Rat
Dog
G protein subunit alpha transducin 1
Horse
G protein subunit alpha transducin 1 [Source:HGNC Symbol;Acc:HGNC:4393]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11488-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Activation of the phototransduction cascade (R-HSA-2485179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Reactome
G alpha (i) signalling events
Reactome
G-protein activation
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G alpha (i) signalling events
G-protein activation
Gene Ontology Terms (37)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (130)
1 – 10 of 130
DNAJC6
Tbio
Family: Enzyme
Novelty: 0.01359669
p_int: 0.999992553
p_ni: 0.000004971
p_wrong: 0.000002475
Score: 0.699
Data Source: BioPlex,STRINGDB
ARL5B
Tbio
Family: Enzyme
Novelty: 0.03703395
p_int: 0.957445557
p_ni: 0.042554383
p_wrong: 6e-8
Score: 0.321
Data Source: BioPlex,STRINGDB
RHO
Tbio
Family: GPCR
Novelty: 0.00012925
Score: 0.991
Data Source: Reactome,STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.989
Data Source: Reactome,STRINGDB
CNGB1
Tbio
Family: IC
Novelty: 0.01034916
Score: 0.988
Data Source: STRINGDB
PDE6G
Tclin
Family: Enzyme
Novelty: 0.03113994
Score: 0.988
Data Source: Reactome,STRINGDB
RGS9
Tbio
Novelty: 0.06662559
Score: 0.98
Data Source: STRINGDB
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.976
Data Source: Reactome,STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.975
Data Source: Reactome,STRINGDB
PDE6B
Tclin
Family: Enzyme
Novelty: 0.001105
Score: 0.972
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  33.49

PubMed score by year
PubTator Score  18.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer