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Tbio
FGF3
Fibroblast growth factor 3

Protein Summary
Description
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334134
  • ENSP00000334122
  • ENSG00000186895

Symbol
  • INT2
  • INT2
  • HBGF-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.71
cell type or tissue
0.62
biological process
0.6
pathway
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.24   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.24   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (212)
XRN1
Tbio
Family:  Enzyme
Novelty:  0.00409381
p_int:  0.999022924
p_ni:  0.000977073
p_wrong:  3e-9
Data Source:  BioPlex
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.998699811
p_ni:  0.001300188
p_wrong:  2e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
ANKRD17
Tbio
Novelty:  0.03177323
p_int:  0.996209804
p_ni:  0.003790196
Data Source:  BioPlex
ZNF100
Tdark
Family:  TF
Novelty:  0.74439926
p_int:  0.995585552
p_ni:  0.002579881
p_wrong:  0.001834568
Score:  0.151
Data Source:  BioPlex,STRINGDB
ZNF593
Tbio
Novelty:  0.45276787
p_int:  0.992999488
p_ni:  0.007000473
p_wrong:  3.9e-8
Data Source:  BioPlex
TMED4
Tdark
Novelty:  0.22372593
p_int:  0.989200473
p_ni:  0.010799527
Data Source:  BioPlex
NUCB1
Tchem
Novelty:  0.0040312
p_int:  0.988794845
p_ni:  0.011205154
Data Source:  BioPlex
CDKN2AIP
Tbio
Novelty:  0.15331029
p_int:  0.984553098
p_ni:  0.015446698
p_wrong:  2.03e-7
Data Source:  BioPlex
GTPBP10
Tbio
Novelty:  0.18563864
p_int:  0.981463731
p_ni:  0.018062079
p_wrong:  0.00047419
Data Source:  BioPlex
YTHDC2
Tbio
Family:  Enzyme
Novelty:  0.05211009
p_int:  0.979866465
p_ni:  0.020133535
Data Source:  BioPlex
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
1 – 5 of 18
FGFR4
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
EGFR
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
IGF1R
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  7
more:  3 more common pathways
Pathways (73)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 49
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
37.6
1
1
0
1.3
24.3
Hemifacial microsomia
1
1
0
1.7
15.6
sex hormone-binding globulin measurement
2
1
2
14.1
synophrys measurement
1
1
1
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
37.6
0
1.3
24.3
Hemifacial microsomia
0
1.7
15.6
sex hormone-binding globulin measurement
2
14.1
synophrys measurement
1
9.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95517
14174
Rat
RGD:620126
170633
Cow
fibroblast growth factor 3
VGNC:28979
618481
Opossum
fibroblast growth factor 3
100021692
Platypus
fibroblast growth factor 3
100075300
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
fibroblast growth factor 3
Opossum
fibroblast growth factor 3
Platypus
fibroblast growth factor 3
Publication Statistics
PubMed Score 202.24
PubMed score by year
PubTator Score 259.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title