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Tbio
FGF3
Fibroblast growth factor 3

Protein Summary
Description
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334134
  • ENSP00000334122
  • ENSG00000186895

Symbol
  • INT2
  • INT2
  • HBGF-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.71
cell type or tissue
0.62
biological process
0.6
pathway
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.24   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.24   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Protein-Protein Interactions (212)
1 – 10 of 212
XRN1
Tbio
Family:  Enzyme
Novelty:  0.00409381
p_int:  0.999022924
p_ni:  0.000977073
p_wrong:  3e-9
Data Source:  BioPlex
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.998699811
p_ni:  0.001300188
p_wrong:  2e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
ANKRD17
Tbio
Novelty:  0.03177323
p_int:  0.996209804
p_ni:  0.003790196
Data Source:  BioPlex
ZNF100
Tdark
Family:  TF
Novelty:  0.74439926
p_int:  0.995585552
p_ni:  0.002579881
p_wrong:  0.001834568
Score:  0.151
Data Source:  BioPlex,STRINGDB
ZNF593
Tbio
Novelty:  0.45276787
p_int:  0.992999488
p_ni:  0.007000473
p_wrong:  3.9e-8
Data Source:  BioPlex
TMED4
Tdark
Novelty:  0.22372593
p_int:  0.989200473
p_ni:  0.010799527
Data Source:  BioPlex
NUCB1
Tchem
Novelty:  0.0040312
p_int:  0.988794845
p_ni:  0.011205154
Data Source:  BioPlex
CDKN2AIP
Tbio
Novelty:  0.15331029
p_int:  0.984553098
p_ni:  0.015446698
p_wrong:  2.03e-7
Data Source:  BioPlex
GTPBP10
Tbio
Novelty:  0.18563864
p_int:  0.981463731
p_ni:  0.018062079
p_wrong:  0.00047419
Data Source:  BioPlex
YTHDC2
Tbio
Family:  Enzyme
Novelty:  0.05211009
p_int:  0.979866465
p_ni:  0.020133535
Data Source:  BioPlex
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
37.6
1
1
0
1.3
24.3
Hemifacial microsomia
1
1
0
1.7
15.6
sex hormone-binding globulin measurement
2
1
2
14.1
synophrys measurement
1
1
1
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
37.6
0
1.3
24.3
Hemifacial microsomia
0
1.7
15.6
sex hormone-binding globulin measurement
2
14.1
synophrys measurement
1
9.9
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95517
14174
Rat
RGD:620126
170633
Cow
fibroblast growth factor 3
VGNC:28979
618481
Opossum
fibroblast growth factor 3
100021692
Platypus
fibroblast growth factor 3
100075300
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
fibroblast growth factor 3
Opossum
fibroblast growth factor 3
Platypus
fibroblast growth factor 3
Publication Statistics
PubMed Score 202.24
PubMed score by year
PubTator Score 259.27
PubTator score by year