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Tbio
FGF3
Fibroblast growth factor 3

Protein Summary
Description
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334134
  • ENSP00000334122
  • ENSG00000186895

Symbol
  • INT2
  • INT2
  • HBGF-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.71
cell type or tissue
0.62
biological process
0.6
pathway
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.64   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.64   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (73)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 49
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (212)
1 – 10 of 212
XRN1
Tbio
Family: Enzyme
Novelty: 0.00630563
p_int: 0.999022924
p_ni: 0.000977073
p_wrong: 3e-9
Data Source: BioPlex
ANKHD1
Tbio
Novelty: 0.08323329
p_int: 0.998699811
p_ni: 0.001300188
p_wrong: 2e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
ANKRD17
Tbio
Novelty: 0.05032241
p_int: 0.996209804
p_ni: 0.003790196
Data Source: BioPlex
ZNF100
Tdark
Family: TF
p_int: 0.995585552
p_ni: 0.002579881
p_wrong: 0.001834568
Score: 0.151
Data Source: BioPlex,STRINGDB
ZNF593
Tbio
Novelty: 0.90909091
p_int: 0.992999488
p_ni: 0.007000473
p_wrong: 3.9e-8
Data Source: BioPlex
TMED4
Tbio
Novelty: 0.01545983
p_int: 0.989200473
p_ni: 0.010799527
Data Source: BioPlex
NUCB1
Tchem
Novelty: 0.00141462
p_int: 0.988794845
p_ni: 0.011205154
Data Source: BioPlex
CDKN2AIP
Tbio
Novelty: 0.20403206
p_int: 0.984553098
p_ni: 0.015446698
p_wrong: 2.03e-7
Data Source: BioPlex
GTPBP10
Tdark
Novelty: 0.25578563
p_int: 0.981463731
p_ni: 0.018062079
p_wrong: 0.00047419
Data Source: BioPlex
YTHDC2
Tbio
Family: Enzyme
Novelty: 0.18840993
p_int: 0.979866465
p_ni: 0.020133535
Data Source: BioPlex
Publication Statistics
PubMed Score  174.64

PubMed score by year
PubTator Score  259.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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