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Tchem
ESRRA
Steroid hormone receptor ERR1

Protein Summary
Description
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000000442
  • ENSP00000000442
  • ENSG00000173153
  • ENST00000405666
  • ENSP00000384851
  • ENST00000406310
  • ENSP00000385971

Symbol
  • ERR1
  • ESRL1
  • NR3B1
  • ERR1
  • ERRa
  • ESRL1
  • NR3B1
  • ERRalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.92
transcription factor binding site profile
0.91
transcription factor
0.88
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.89   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 488   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.89   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 488   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 89
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (89)
Protein-Protein Interactions (68)
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.999998984
p_wrong:  0.000001016
Score:  0.225
Data Source:  BioPlex,STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
p_int:  0.998276647
p_ni:  1.3e-8
p_wrong:  0.00172334
Score:  0.171
Data Source:  BioPlex,STRINGDB
PPARGC1A
Tbio
Novelty:  0.0003625
Score:  0.999
Data Source:  Reactome,STRINGDB
PPARGC1B
Tbio
Novelty:  0.01004477
Score:  0.957
Data Source:  Reactome,STRINGDB
NRF1
Tbio
Family:  TF
Novelty:  0.00543248
Score:  0.953
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.941
Data Source:  STRINGDB
NRIP1
Tbio
Novelty:  0.00551568
Score:  0.936
Data Source:  STRINGDB
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
Score:  0.929
Data Source:  STRINGDB
PPARA
Tclin
Family:  NR
Novelty:  0.00017403
Score:  0.927
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (37)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial biogenesis
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Mitochondrial biogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
6
7
97.1
BMI-adjusted waist-hip ratio
6
6
10
97.1
urate measurement
1
4
4
94.5
triglyceride measurement
4
3
4
93.5
high density lipoprotein cholesterol measurement
5
3
5
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
7
97.1
BMI-adjusted waist-hip ratio
10
97.1
urate measurement
4
94.5
triglyceride measurement
4
93.5
high density lipoprotein cholesterol measurement
5
92.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
estrogen related receptor alpha
VGNC:6555
466651
Macaque
estrogen related receptor alpha
722085
Mouse
MGI:1346831
26379
Rat
RGD:1583866
293701
Dog
estrogen related receptor alpha
VGNC:54270
403169
Species
Name
OMA
EggNOG
Inparanoid
Chimp
estrogen related receptor alpha
Macaque
estrogen related receptor alpha
Mouse
Rat
Dog
estrogen related receptor alpha
Publication Statistics
PubMed Score 382.89
PubMed score by year
PubTator Score 180.48
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title