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Tchem
ESRRA
Steroid hormone receptor ERR1

Protein Summary
Description
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000000442
  • ENSP00000000442
  • ENSG00000173153
  • ENST00000405666
  • ENSP00000384851
  • ENST00000406310
  • ENSP00000385971

Symbol
  • ERR1
  • ESRL1
  • NR3B1
  • ERR1
  • ERRa
  • ESRL1
  • NR3B1
  • ERRalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.92
transcription factor binding site profile
0.91
transcription factor
0.88
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.16   (req: < 5)
Gene RIFs: 158   (req: <= 3)
Antibodies: 488   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.16   (req: >= 5)
Gene RIFs: 158   (req: > 3)
Antibodies: 488   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 89
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3