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Tclin
VDR
Vitamin D3 receptor

Protein Summary
Description
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229022
  • ENSP00000229022
  • ENSG00000111424
  • ENST00000395324
  • ENSP00000378734
  • ENST00000549336
  • ENSP00000449573
  • ENST00000550325
  • ENSP00000447173

Symbol
  • NR1I1
  • NR1I1
  • PPP1R163
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
virus perturbation
0.98
hub protein
0.97
chemical
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1240.33   (req: < 5)
Gene RIFs: 1346   (req: <= 3)
Antibodies: 722   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1240.33   (req: >= 5)
Gene RIFs: 1346   (req: > 3)
Antibodies: 722   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 101
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
61.7
inflammatory biomarker measurement
1
1
0
47.6
50.9
gut microbiome measurement
1
1
1
28.4
Diuretic use measurement
1
1
1
13.9
eosinophil percentage of leukocytes
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
61.7
inflammatory biomarker measurement
0
47.6
50.9
gut microbiome measurement
1
28.4
Diuretic use measurement
1
13.9
eosinophil percentage of leukocytes
1
13.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
vitamin D receptor
706964
Mouse
MGI:103076
22337
Rat
RGD:3959
24873
Dog
vitamin D receptor
VGNC:48249
486588
Horse
vitamin D receptor
VGNC:24898
100034072
Species
Name
OMA
EggNOG
Inparanoid
Macaque
vitamin D receptor
Mouse
Rat
Dog
vitamin D receptor
Horse
vitamin D receptor
Protein Data Bank (49)
1 – 5 of 49
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (124)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Metabolism of proteins
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (202)
1 – 10 of 202
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.988
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.974
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.969
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.968
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.964
Data Source: STRINGDB
BAZ1B
Tbio
Family: Epigenetic
Novelty: 0.02374034
Score: 0.962
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.955
Data Source: STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.944
Data Source: STRINGDB
RXRB
Tclin
Family: NR
Novelty: 0.01503977
Score: 0.94
Data Source: STRINGDB
RXRG
Tclin
Family: NR
Novelty: 0.01646377
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  1240.33

PubMed score by year
PubTator Score  4259.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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