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Tclin
VDR
Vitamin D3 receptor

Protein Summary
Description
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229022
  • ENSP00000229022
  • ENSG00000111424
  • ENST00000395324
  • ENSP00000378734
  • ENST00000549336
  • ENSP00000449573
  • ENST00000550325
  • ENSP00000447173

Symbol
  • NR1I1
  • NR1I1
  • PPP1R163
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.99
virus perturbation
0.98
hub protein
0.97
chemical
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1523.16   (req: < 5)
Gene RIFs: 1346   (req: <= 3)
Antibodies: 722   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1523.16   (req: >= 5)
Gene RIFs: 1346   (req: > 3)
Antibodies: 722   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 246
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9