Protein Summary
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are as ...more
- ENST00000229022
- ENSP00000229022
- ENSG00000111424
- ENST00000395324
- ENSP00000378734
- ENST00000549336
- ENSP00000449573
- ENST00000550325
- ENSP00000447173
- NR1I1
- NR1I1
- PPP1R163
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
biological process | 0.99 | ||
virus perturbation | 0.98 | ||
hub protein | 0.97 | ||
chemical | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1268.13 (req: < 5)
Gene RIFs: 1346 (req: <= 3)
Antibodies: 722 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1268.13 (req: >= 5)
Gene RIFs: 1346 (req: > 3)
Antibodies: 722 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 41
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 240
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 9
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (9)
Active Ligands (240)
Protein-Protein Interactions (202)
Nearest Tclin Targets
Pathways (124)
Reactome (13)
KEGG (4)
PathwayCommons (8)
WikiPathways (99)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (46)
Functions (15)
Components (5)
Processes (26)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (37)
Items per page:
1 – 5 of 37
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
HbA1c measurement | 2 | 6 | 6 | 96 | |||||
platelet count | 2 | 4 | 4 | 95.2 | |||||
platelet crit | 2 | 5 | 5 | 94.6 | |||||
lymphocyte count | 3 | 2 | 4 | 87.6 | |||||
mean platelet volume | 2 | 2 | 3 | 82.5 | |||||
Items per page:
1 – 5 of 37
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
HbA1c measurement | 6 | 96 | |||||
platelet count | 4 | 95.2 | |||||
platelet crit | 5 | 94.6 | |||||
lymphocyte count | 4 | 87.6 | |||||
mean platelet volume | 3 | 82.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | vitamin D receptor | 706964 | ||||||
Mouse | MGI:103076 | 22337 | ||||||
Rat | RGD:3959 | 24873 | ||||||
Dog | vitamin D receptor | VGNC:48249 | 486588 | |||||
Horse | vitamin D receptor | VGNC:24898 | 100034072 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | vitamin D receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | vitamin D receptor | |||||
Horse | vitamin D receptor | |||||
Publication Statistics
PubMed Score 1268.13
PubMed score by year
PubTator Score 4259.25
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (1814)
GeneRif Annotations (1346)
Items per page:
0 of 0
PMID | Year | Title |
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