Protein Classes
Protein Summary
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:28698609, PubMed:16913708, PubMed:15728261, PubMed:10678179). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (PubMed:28698609). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (PubMed:28698609). Plays a central role in calcium homeostasis (By similarity). This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are as ...more
- ENST00000229022
- ENSP00000229022
- ENSG00000111424
- ENST00000395324
- ENSP00000378734
- ENST00000549336
- ENSP00000449573
- ENST00000550325
- ENSP00000447173
- NR1I1
- NR1I1
- PPP1R163
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
biological process | 0.99 | ||
virus perturbation | 0.98 | ||
hub protein | 0.97 | ||
chemical | 0.95 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1240.33 (req: < 5)
Gene RIFs: 1346 (req: <= 3)
Antibodies: 722 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1240.33 (req: >= 5)
Gene RIFs: 1346 (req: > 3)
Antibodies: 722 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 41
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 101
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 9
Approved Drugs (9)
1 – 9 of 9
Active Ligands (101)
1 – 10 of 101
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 1 | 1 | 1 | 61.7 | |||||
inflammatory biomarker measurement | 1 | 1 | 0 | 47.6 | 50.9 | ||||
gut microbiome measurement | 1 | 1 | 1 | 28.4 | |||||
Diuretic use measurement | 1 | 1 | 1 | 13.9 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 13.2 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 1 | 61.7 | |||||
inflammatory biomarker measurement | 0 | 47.6 | 50.9 | ||||
gut microbiome measurement | 1 | 28.4 | |||||
Diuretic use measurement | 1 | 13.9 | |||||
eosinophil percentage of leukocytes | 1 | 13.2 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | vitamin D receptor | 706964 | ||||||
Mouse | MGI:103076 | 22337 | ||||||
Rat | RGD:3959 | 24873 | ||||||
Dog | vitamin D receptor | VGNC:48249 | 486588 | |||||
Horse | vitamin D receptor | VGNC:24898 | 100034072 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | vitamin D receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | vitamin D receptor | |||||
Horse | vitamin D receptor | |||||
Protein Structure (49 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 49
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (124)
Reactome (13)
KEGG (4)
PathwayCommons (8)
WikiPathways (99)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of proteins | ||||
Gene Ontology Terms (46)
Functions (15)
Components (5)
Processes (26)
Items per page:
10
1 – 10 of 15
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (202)
1 – 10 of 202
MED1
Family: Enzyme
Novelty: 0.00852082
Score: 0.988
Data Source: STRINGDB
NCOA1
Family: Epigenetic
Novelty: 0.00344663
Score: 0.974
Data Source: STRINGDB
EP300
Family: Epigenetic
Novelty: 0.00055009
Score: 0.969
Data Source: STRINGDB
SMAD3
Family: TF
Novelty: 0.00048058
Score: 0.968
Data Source: STRINGDB
CREBBP
Family: Epigenetic
Novelty: 0.00111166
Score: 0.964
Data Source: STRINGDB
BAZ1B
Family: Epigenetic
Novelty: 0.02374034
Score: 0.962
Data Source: STRINGDB
RXRA
Family: NR
Novelty: 0.00244343
Score: 0.955
Data Source: STRINGDB
SMAD4
Family: TF
Novelty: 0.00047069
Score: 0.944
Data Source: STRINGDB
RXRB
Family: NR
Novelty: 0.01503977
Score: 0.94
Data Source: STRINGDB
RXRG
Family: NR
Novelty: 0.01646377
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score 1240.33
PubMed score by year
PubTator Score 4259.25
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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