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Tbio
UBL4A
Ubiquitin-like protein 4A

Protein Summary
Description
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369660
  • ENSP00000358674
  • ENSG00000102178

Symbol
  • DXS254E
  • GDX
  • UBL4
  • GDX
  • G6PD
  • GET5
  • MDY2
  • UBL4
  • TMA24
  • DX254E
  • DXS254E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
disease perturbation
0.68
histone modification site profile
0.68
tissue sample
0.68
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.58   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.58   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
13.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
13.6
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Protein localization
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (305)
1 – 10 of 305
RPS6KB1
Tchem
Family: Kinase
Novelty: 0.00044681
p_int: 0.999519845
p_ni: 0.000478804
p_wrong: 0.000001351
Score: 0.69
Data Source: BioPlex,STRINGDB
GET4
Tbio
Novelty: 0.03516005
p_int: 0.998498408
p_ni: 0.001501592
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
BAG6
Tbio
Novelty: 0.0035578
p_int: 0.992479775
p_ni: 0.007520225
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.982
Data Source: STRINGDB
ASNA1
Tbio
Family: Enzyme
Novelty: 0.01260233
Score: 0.922
Data Source: Reactome,STRINGDB
USP13
Tchem
Family: Enzyme
Novelty: 0.03470844
Score: 0.906
Data Source: STRINGDB
SGTA
Tbio
Novelty: 0.01488022
Score: 0.893
Data Source: Reactome,STRINGDB
RNF126
Tbio
Family: Enzyme
Novelty: 0.08123801
Score: 0.854
Data Source: STRINGDB
NPLOC4
Tbio
Novelty: 0.01690434
Score: 0.84
Data Source: STRINGDB
ERP27
Tbio
Novelty: 0.23824089
Score: 0.826
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.58

PubMed score by year
PubTator Score  404.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer