Tchem G6PD Glucose-6-phosphate 1-dehydrogenase

Protein Summary

Description

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P11413
• D3DWX9
• Q16000
• Q16765
• Q8IU70
• Q8IU88
• Q8IUA6
• Q96PQ2
• G6PD

Gene Name

• G6PD

Ensembl ID

• ENST00000369620
• ENSP00000358633
• ENSG00000160211
• ENST00000393562
• ENSP00000377192
• ENST00000393564
• ENSP00000377194
• ENST00000621232
• ENSP00000483686

Symbol

• G6PD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.98
transcription factor perturbation	0.97
biological process	0.87
cellular component	0.85
histone modification site profile	0.83

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Glucose-6-phosphate 1-dehydrogenase

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Glucose-6-phosphate 1-dehydrogenase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1645.42   (req: < 5)

Gene RIFs: 332   (req: <= 3)

Antibodies: 678   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1645.42   (req: >= 5)

Gene RIFs: 332   (req: > 3)

Antibodies: 678   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0