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Tchem
G6PD
Glucose-6-phosphate 1-dehydrogenase

Protein Summary
Description
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 20 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369620
  • ENSP00000358633
  • ENSG00000160211
  • ENST00000393562
  • ENSP00000377192
  • ENST00000393564
  • ENSP00000377194
  • ENST00000621232
  • ENSP00000483686

Symbol
  • G6PD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.98
transcription factor perturbation
0.97
biological process
0.87
cellular component
0.85
histone modification site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1384.04   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 678   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1384.04   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 678   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (309)
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  0.996418302
p_ni:  0.003581697
Score:  0.177
Data Source:  BioPlex,STRINGDB
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.989737823
p_ni:  0.010262177
Score:  0.247
Data Source:  BioPlex,STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
p_int:  0.909761439
p_ni:  0.090238561
Score:  0.161
Data Source:  BioPlex,STRINGDB
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.862862046
p_ni:  0.137137954
Score:  0.151
Data Source:  BioPlex,STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.994
Data Source:  STRINGDB
PGD
Tchem
Family:  Enzyme
Novelty:  0.00576529
Score:  0.993
Data Source:  STRINGDB
PGLS
Tbio
Family:  Enzyme
Novelty:  0.03252394
Score:  0.992
Data Source:  STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
Score:  0.989
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
TPI1
Tbio
Family:  Enzyme
Novelty:  0.00074652
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (66)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Pentose phosphate pathway
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of carbohydrates
Pentose phosphate pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
1
3
87.7
red blood cell distribution width
1
1
1
79.3
erythrocyte count
1
1
1
70.2
hemolysis
1
1
0
3.8
68.3
neutrophil count
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
3
87.7
red blood cell distribution width
1
79.3
erythrocyte count
1
70.2
hemolysis
0
3.8
68.3
neutrophil count
1
36.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glucose-6-phosphate dehydrogenase
701137
Mouse
MGI:105979
14381
Rat
RGD:2645
24377
Dog
glucose-6-phosphate dehydrogenase
VGNC:41043
481088
Horse
glucose-6-phosphate dehydrogenase
VGNC:18183
100059734
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glucose-6-phosphate dehydrogenase
Mouse
Rat
Dog
glucose-6-phosphate dehydrogenase
Horse
glucose-6-phosphate dehydrogenase
Publication Statistics
PubMed Score 1384.04
PubMed score by year
PubTator Score 6673.42
PubTator score by year
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Related Publications
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PMID
Year
Title