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Tclin
TOP2A
DNA topoisomerase 2-alpha

Protein Summary
Description
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to ch ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
protein domain
1
drug perturbation
0.96
kinase
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 831.61   (req: < 5)
Gene RIFs: 311   (req: <= 3)
Antibodies: 1266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 831.61   (req: >= 5)
Gene RIFs: 311   (req: > 3)
Antibodies: 1266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1
1
27.4
sex hormone-binding globulin measurement
2
1
2
19.3
hip circumference
1
1
1
16.3
neutrophil percentage of leukocytes
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
27.4
sex hormone-binding globulin measurement
2
19.3
hip circumference
1
16.3
neutrophil percentage of leukocytes
1
7.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA topoisomerase II alpha
VGNC:9732
454651
Mouse
MGI:98790
21973
Rat
RGD:62048
360243
Dog
DNA topoisomerase II alpha
VGNC:49098
480525
Horse
DNA topoisomerase II alpha
VGNC:50516
100054229
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA topoisomerase II alpha
Mouse
Rat
Dog
DNA topoisomerase II alpha
Horse
DNA topoisomerase II alpha
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11388-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G0 and Early G1
Reactome
Metabolism of proteins
Reactome
Mitotic G1-G1/S phases
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G0 and Early G1
Metabolism of proteins
Mitotic G1-G1/S phases
Gene Ontology Terms (42)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (451)
1 – 10 of 451
ASB3
Tbio
Novelty: 0.15921018
p_int: 0.999868658
p_ni: 0.00013134
p_wrong: 2e-9
Score: 0.248
Data Source: BioPlex,STRINGDB
HSD3B2
Tclin
Family: Enzyme
Novelty: 0.00711552
p_int: 0.999582935
p_ni: 0.000417012
p_wrong: 5.4e-8
Score: 0.172
Data Source: BioPlex,STRINGDB
FAM131B
Tdark
Novelty: 0.3424123
p_int: 0.996340577
p_ni: 0.0036594
p_wrong: 2.3e-8
Score: 0.186
Data Source: BioPlex,STRINGDB
THBS3
Tbio
Novelty: 0.01915634
p_int: 0.993070313
p_ni: 0.006929398
p_wrong: 2.89e-7
Data Source: BioPlex
CAPN2
Tchem
Novelty: 0.00431673
p_int: 0.975628993
p_ni: 0.024370337
p_wrong: 6.7e-7
Data Source: BioPlex
RBM4B
Tdark
Novelty: 0.33151475
p_int: 0.957488502
p_ni: 0.011007899
p_wrong: 0.031503599
Score: 0.181
Data Source: BioPlex,STRINGDB
INTU
Tbio
Novelty: 0.02714388
p_int: 0.957064952
p_ni: 0.035509001
p_wrong: 0.007426047
Score: 0.169
Data Source: BioPlex,STRINGDB
DRC3
Tdark
Novelty: 0.99283468
p_int: 0.915829901
p_ni: 0.079061483
p_wrong: 0.005108616
Data Source: BioPlex
PIAS4
Tbio
Family: TF
Novelty: 0.01388547
p_int: 0.9011385
p_ni: 0.092062131
p_wrong: 0.006799369
Score: 0.946
Data Source: BioPlex,STRINGDB
CDH19
Tbio
Novelty: 0.0759041
p_int: 0.854336715
p_ni: 0.14220736
p_wrong: 0.003455925
Score: 0.201
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  831.61

PubMed score by year
PubTator Score  586.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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