Protein Classes
Protein Summary
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR resp ...more
- ENST00000361337
- ENSP00000354522
- ENSG00000198900
- TOPI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
interacting protein | 1 | ||
protein domain | 1 | ||
transcription factor perturbation | 0.96 | ||
molecular function | 0.95 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4950 (req: < 5)
Gene RIFs: 180 (req: <= 3)
Antibodies: 382 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4950 (req: >= 5)
Gene RIFs: 180 (req: > 3)
Antibodies: 382 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 139
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Approved Drugs (4)
1 – 4 of 4
Active Ligands (139)
1 – 10 of 139
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 3 | 2 | 5 | 93.7 | |||||
total cholesterol measurement | 2 | 1 | 3 | 79.5 | |||||
BMI-adjusted waist-hip ratio | 1 | 1 | 1 | 78.7 | |||||
waist-hip ratio | 1 | 1 | 1 | 69.6 | |||||
hemoglobin measurement | 2 | 1 | 2 | 66.9 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 5 | 93.7 | |||||
total cholesterol measurement | 3 | 79.5 | |||||
BMI-adjusted waist-hip ratio | 1 | 78.7 | |||||
waist-hip ratio | 1 | 69.6 | |||||
hemoglobin measurement | 2 | 66.9 | |||||
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DNA topoisomerase I | VGNC:10014 | 458252 | |||||
Macaque | DNA topoisomerase I | 697300 | ||||||
Mouse | MGI:98788 | 21969 | ||||||
Rat | RGD:621246 | 64550 | ||||||
Dog | DNA topoisomerase I | VGNC:49631 | 477229 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DNA topoisomerase I | |||||
Macaque | DNA topoisomerase I | |||||
Mouse | ||||||
Rat | ||||||
Dog | DNA topoisomerase I | |||||
Protein Structure (15 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 15
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (10)
Reactome (5)
PathwayCommons (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | SUMO E3 ligases SUMOylate target proteins | ||||
Reactome | SUMOylation | ||||
Reactome | SUMOylation of DNA replication proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
SUMO E3 ligases SUMOylate target proteins | ||||
SUMOylation | ||||
SUMOylation of DNA replication proteins | ||||
Gene Ontology Terms (32)
Functions (11)
Components (9)
Processes (12)
Items per page:
10
1 – 10 of 11
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Protein-Protein Interactions (286)
1 – 10 of 286
EAF1
Novelty: 0.81120425
p_int: 0.99560056
p_ni: 0.00439944
Data Source: BioPlex
ZRANB2
Novelty: 0.06105086
p_int: 0.992838763
p_ni: 0.007161237
Score: 0.556
Data Source: BioPlex,STRINGDB
ESAM
Novelty: 0.00462452
p_int: 0.952336066
p_ni: 0.047663934
Score: 0.19
Data Source: BioPlex,STRINGDB
CIDEC
Novelty: 0.01081754
p_int: 0.910968099
p_ni: 0.089031901
Score: 0.252
Data Source: BioPlex,STRINGDB
HDGFL2
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.901074525
p_ni: 0.098925475
Data Source: BioPlex
SNRPGP15
p_int: 0.89344272
p_ni: 0.10655728
Data Source: BioPlex
PRICKLE3
Novelty: 0.26347141
p_int: 0.882610129
p_ni: 0.117389871
Data Source: BioPlex
DUS4L
Family: Enzyme
Novelty: 0.05943255
p_int: 0.860040648
p_ni: 0.139959352
Score: 0.209
Data Source: BioPlex,STRINGDB
GTF2E2
Novelty: 0.18033153
p_int: 0.809584398
p_ni: 0.190415602
Score: 0.219
Data Source: BioPlex,STRINGDB
TOP2A
Family: Enzyme
Novelty: 0.00122788
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score 4950.00
PubMed score by year
PubTator Score 69.41
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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