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Tbio
ERG
Transcriptional regulator ERG

Protein Summary
Description
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prosta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288319
  • ENSP00000288319
  • ENSG00000157554
  • ENST00000398897
  • ENSP00000381871
  • ENST00000398911
  • ENSP00000381882
  • ENST00000398919
  • ENSP00000381891
  • ENST00000417133
  • ENSP00000414150
  • ENST00000442448
  • ENSP00000394694

Symbol
  • p55
  • erg-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.92
trait
0.86
cell type or tissue
0.76
transcription factor
0.76
microRNA
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: < 5)
Gene RIFs: 354   (req: <= 3)
Antibodies: 511   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: >= 5)
Gene RIFs: 354   (req: > 3)
Antibodies: 511   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
1
2
84.1
leukocyte count
2
2
2
83.7
red blood cell density measurement
1
1
1
76
mean corpuscular hemoglobin concentration
1
1
1
75.8
hematocrit
2
2
2
73.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
84.1
leukocyte count
2
83.7
red blood cell density measurement
1
76
mean corpuscular hemoglobin concentration
1
75.8
hematocrit
2
73.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ERG, ETS transcription factor
VGNC:14662
473995
Macaque
ERG, ETS transcription factor
693300
Mouse
MGI:95415
13876
Rat
RGD:621108
170909
Dog
ERG, ETS transcription factor
VGNC:40448
487760
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ERG, ETS transcription factor
Macaque
ERG, ETS transcription factor
Mouse
Rat
Dog
ERG, ETS transcription factor
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
NTNU_SB
Protein-Protein Interactions (31)
1 – 10 of 31
TMPRSS2
Tchem
Family: Enzyme
Novelty: 0.00117884
Score: 0.726
Data Source: STRINGDB
SRSF10
Tbio
Novelty: 0.01273022
Score: 0.718
Data Source: STRINGDB
KCNH6
Tclin
Family: IC
Novelty: 0.01126636
Score: 0.638
Data Source: STRINGDB
TMEM41A
Tdark
Novelty: 1.49362751
Score: 0.635
Data Source: STRINGDB
SPI1
Tbio
Family: TF
Novelty: 0.00064309
Score: 0.632
Data Source: STRINGDB
CDH5
Tbio
Novelty: 0.00072649
Score: 0.63
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.593
Data Source: STRINGDB
LMO2
Tbio
Novelty: 0.0038279
Score: 0.543
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.542
Data Source: STRINGDB
SRSF2
Tbio
Novelty: 0.00207072
Score: 0.528
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.77

PubMed score by year
PubTator Score  2492.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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