Tbio ERG Transcriptional regulator ERG

Protein Summary

Description

Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• P11308
• B4DTW5
• B4E0T4
• Q16113
• Q6XXX4
• Q6XXX5
• Q8IXK9

Gene Name

• ERG

Ensembl ID

• ENST00000288319
• ENSP00000288319
• ENSG00000157554
• ENST00000398897
• ENSP00000381871
• ENST00000398911
• ENSP00000381882
• ENST00000398919
• ENSP00000381891
• ENST00000417133
• ENSP00000414150
• ENST00000442448
• ENSP00000394694

Symbol

• p55
• erg-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.92
trait	0.86
cell type or tissue	0.76
transcription factor	0.76
microRNA	0.71

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcriptional Regulator Erg

Protein / Signaling Molecule / Transcriptional Regulator Erg

Protein / Nucleic Acid Binding / Transcriptional Regulator Erg

Protein / ... / Winged Helix/forkhead Transcription Factor / Transcriptional Regulator Erg

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Transcriptional Regulator Erg

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.19   (req: < 5)

Gene RIFs: 433   (req: <= 3)

Antibodies: 511   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.19   (req: >= 5)

Gene RIFs: 433   (req: > 3)

Antibodies: 511   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0