Tbio LAMP1 Lysosome-associated membrane glycoprotein 1

Protein Summary

Description

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. Acts as a receptor for Lassa virus protein. The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P11279
• B4DWL3
• Q8WU33
• Q96I40
• Q9BRD2
• Q9NP13
• LAMP-1

Gene Name

• LAMP1

Ensembl ID

• ENST00000332556
• ENSP00000333298
• ENSG00000185896

Symbol

• LAMPA
• CD107a
• LGP120

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
cellular component	0.98
interacting protein	0.98
kinase perturbation	0.98
transcription factor binding site profile	0.88

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Lysosome-associated Membrane Glycoprotein 1

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Lysosome-associated Membrane Glycoprotein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1668.65   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 1259   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1668.65   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 1259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0