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Tbio
LAMP1
Lysosome-associated membrane glycoprotein 1

Protein Summary
Description
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. Acts as a receptor for Lassa virus protein. The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332556
  • ENSP00000333298
  • ENSG00000185896

Symbol
  • LAMPA
  • CD107a
  • LGP120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
cellular component
0.98
interacting protein
0.98
kinase perturbation
0.98
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1346.12   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 1259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1346.12   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 1259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (24)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (36)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (446)
1 – 10 of 446
STK17B
Tchem
Family: Kinase
Novelty: 0.0420158
p_int: 0.999989527
p_ni: 0.000006822
p_wrong: 0.000003651
Score: 0.175
Data Source: BioPlex,STRINGDB
SLC38A7
Tdark
Family: Transporter
Novelty: 0.24353276
p_int: 0.999964617
p_ni: 0.000035383
Score: 0.261
Data Source: BioPlex,STRINGDB
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
p_int: 0.999916751
p_ni: 0.000083249
Score: 0.165
Data Source: BioPlex,STRINGDB
RAB4A
Tbio
Family: Enzyme
Novelty: 0.00423197
p_int: 0.998796671
p_ni: 0.001061256
p_wrong: 0.000142073
Score: 0.708
Data Source: BioPlex,STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
p_int: 0.997485575
p_ni: 0.002514425
Score: 0.22
Data Source: BioPlex,STRINGDB
PLAA
Tchem
Family: Enzyme
Novelty: 0.01164687
p_int: 0.996982699
p_ni: 0.003017301
Score: 0.183
Data Source: BioPlex,STRINGDB
C4A
Tbio
Novelty: 0.00062793
p_int: 0.996151128
p_ni: 0.00384887
p_wrong: 2e-9
Score: 0.192
Data Source: BioPlex,STRINGDB
LEMD3
Tbio
Novelty: 0.00579701
p_int: 0.966033656
p_ni: 0.033966344
Data Source: BioPlex
LGALS1
Tchem
Novelty: 0.00106509
p_int: 0.959440339
p_ni: 0.040536074
p_wrong: 0.000023587
Score: 0.205
Data Source: BioPlex,STRINGDB
ELP6
Tbio
Novelty: 0.01229878
p_int: 0.933119134
p_ni: 0.066870226
p_wrong: 0.00001064
Score: 0.179
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1346.12

PubMed score by year
PubTator Score  609.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer