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Tbio
SPTB
Spectrin beta chain, erythrocytic

Protein Summary
Description
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389720
  • ENSP00000374370
  • ENSG00000070182
  • ENST00000389721
  • ENSP00000374371
  • ENST00000389722
  • ENSP00000374372
  • ENST00000556626
  • ENSP00000451752
  • ENST00000644917
  • ENSP00000495909

Symbol
  • SPTB1
  • EL3
  • HS2
  • SPH2
  • HSPTB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
co-expressed gene
0.72
tissue sample
0.7
disease perturbation
0.68
gene perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.36   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.36   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
RAB40AL
Tbio
Novelty:  0.00908832
p_int:  0.99999752
p_ni:  0.000002315
p_wrong:  1.65e-7
Score:  0.262
Data Source:  BioPlex,STRINGDB
C10orf53
Tdark
Novelty:  4.63758308
p_int:  0.999997269
p_ni:  0.000002731
Data Source:  BioPlex
GLB1L2
Tdark
Family:  Enzyme
Novelty:  1.03866932
p_int:  0.999991686
p_ni:  0.000008311
p_wrong:  4e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
TXNDC5
Tbio
Novelty:  0.02369481
p_int:  0.999991307
p_ni:  0.000008676
p_wrong:  1.7e-8
Score:  0.296
Data Source:  BioPlex,STRINGDB
PAPOLG
Tbio
Family:  Enzyme
Novelty:  0.02468251
p_int:  0.99998069
p_ni:  0.000008904
p_wrong:  0.000010406
Data Source:  BioPlex
CPLX4
Tdark
Novelty:  0.1755035
p_int:  0.999955828
p_ni:  0.000004357
p_wrong:  0.000039816
Score:  0.188
Data Source:  BioPlex,STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
p_int:  0.999904789
p_ni:  0.000062578
p_wrong:  0.000032633
Score:  0.261
Data Source:  BioPlex,STRINGDB
CRP
Tbio
Novelty:  0.00001517
p_int:  0.999872012
p_ni:  0.000036675
p_wrong:  0.000091313
Score:  0.272
Data Source:  BioPlex,STRINGDB
ZBTB12
Tbio
Family:  TF
Novelty:  0.15640131
p_int:  0.999824649
p_ni:  0.000040284
p_wrong:  0.000135067
Score:  0.625
Data Source:  BioPlex,STRINGDB
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.999589956
p_ni:  0.000029492
p_wrong:  0.000380552
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Axon guidance
Reactome
COPI-mediated anterograde transport
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Axon guidance
COPI-mediated anterograde transport
Cytokine Signaling in Immune system
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
10
10
99.7
mean reticulocyte volume
1
6
6
98.7
red blood cell distribution width
4
7
9
98.6
reticulocyte count
4
3
5
96.4
reticulocyte measurement
2
2
3
93.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
10
99.7
mean reticulocyte volume
6
98.7
red blood cell distribution width
9
98.6
reticulocyte count
5
96.4
reticulocyte measurement
3
93.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
spectrin beta, erythrocytic
711142
Mouse
MGI:98387
20741
Rat
RGD:1303243
314251
Dog
spectrin beta, erythrocytic
VGNC:46774
490734
Horse
spectrin beta, erythrocytic
VGNC:23555
100052369
Species
Name
OMA
EggNOG
Inparanoid
Macaque
spectrin beta, erythrocytic
Mouse
Rat
Dog
spectrin beta, erythrocytic
Horse
spectrin beta, erythrocytic
Publication Statistics
PubMed Score 215.36
PubMed score by year
PubTator Score 166.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title