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Tclin
BCR
Breakpoint cluster region protein

Protein Summary
Description
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305877
  • ENSP00000303507
  • ENSG00000186716
  • ENST00000359540
  • ENSP00000352535

Symbol
  • BCR1
  • D22S11
  • ALL
  • CML
  • PHL
  • BCR1
  • D22S11
  • D22S662
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
0.99
protein domain
0.97
kinase
0.91
biological process
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 739.52   (req: < 5)
Gene RIFs: 276   (req: <= 3)
Antibodies: 599   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 739.52   (req: >= 5)
Gene RIFs: 276   (req: > 3)
Antibodies: 599   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ponatinib
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
41.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
41.8
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FGFR1 mutant receptor activation
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
FGFR1 mutant receptor activation
Rho GTPase cycle
Signal Transduction
Gene Ontology Terms (43)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (173)
1 – 10 of 173
PDZK1P1
Tdark
p_int: 0.99999985
p_ni: 1.37e-7
p_wrong: 1.2e-8
Data Source: BioPlex
ERCC3
Tbio
Family: Enzyme
Novelty: 0.00978601
p_int: 0.999996151
p_ni: 0.000003847
p_wrong: 3e-9
Score: 0.559
Data Source: BioPlex,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999989214
p_ni: 0.000010766
p_wrong: 1.9e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.999975954
p_ni: 0.000024046
Data Source: BioPlex
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.999959321
p_ni: 0.000040676
p_wrong: 3e-9
Score: 0.151
Data Source: BioPlex,STRINGDB
COMMD1
Tbio
Novelty: 0.01349432
p_int: 0.999905567
p_ni: 0.000094427
p_wrong: 6e-9
Score: 0.157
Data Source: BioPlex,STRINGDB
TULP3
Tbio
Family: TF
Novelty: 0.06911636
p_int: 0.999868099
p_ni: 0.000131901
Score: 0.162
Data Source: BioPlex,STRINGDB
SEC13
Tbio
Novelty: 0.00709413
p_int: 0.999235738
p_ni: 0.000764262
Score: 0.158
Data Source: BioPlex,STRINGDB
RSPH9
Tbio
Novelty: 0.08651313
p_int: 0.998266831
p_ni: 0.001732867
p_wrong: 3.02e-7
Score: 0.167
Data Source: BioPlex,STRINGDB
CCDC183
Tdark
Novelty: 1.55719016
p_int: 0.992876409
p_ni: 0.007121301
p_wrong: 0.00000229
Data Source: BioPlex
Publication Statistics
PubMed Score  739.52

PubMed score by year
PubTator Score  1199.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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