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Tbio
NAT2
Arylamine N-acetyltransferase 2

Protein Summary
Description
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens. This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
chemical
0.91
disease
0.7
gene perturbation
0.63
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 733.94   (req: < 5)
Gene RIFs: 381   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 733.94   (req: >= 5)
Gene RIFs: 381   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
STARD7
Tbio
Novelty:  0.04511594
p_int:  0.999999408
p_ni:  5.19e-7
p_wrong:  7.3e-8
Score:  0.351
Data Source:  BioPlex,STRINGDB
ZNF346
Tbio
Novelty:  0.00204191
p_int:  0.99999609
p_ni:  0.00000391
Score:  0.548
Data Source:  BioPlex,STRINGDB
KLK5
Tchem
Family:  Enzyme
Novelty:  0.00835407
p_int:  0.950865889
p_ni:  0.000155518
p_wrong:  0.048978593
Score:  0.189
Data Source:  BioPlex,STRINGDB
CYP1A2
Tchem
Novelty:  0.00034756
Score:  0.972
Data Source:  STRINGDB
CYP2E1
Tchem
Novelty:  0.00030504
Score:  0.966
Data Source:  STRINGDB
CYP2A6
Tchem
Novelty:  0.00105285
Score:  0.955
Data Source:  STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
Score:  0.917
Data Source:  STRINGDB
CES1
Tchem
Family:  Enzyme
Novelty:  0.00092608
Score:  0.914
Data Source:  STRINGDB
XDH
Tclin
Family:  Enzyme
Novelty:  0.00054185
Score:  0.909
Data Source:  STRINGDB
NAT1
Tchem
Family:  Enzyme
Novelty:  0.00425955
Score:  0.85
Data Source:  STRINGDB
Pathways (11)
Acetylation (R-HSA-156582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylation
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Acetylation
Biological oxidations
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
14
9
20
3
98.3
blood metabolite measurement
2
4
4
96.6
total cholesterol measurement
5
5
8
85.6
urinary metabolite measurement
2
2
2
80.9
sleep duration
2
2
2
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
20
3
98.3
blood metabolite measurement
4
96.6
total cholesterol measurement
8
85.6
urinary metabolite measurement
2
80.9
sleep duration
2
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acetyltransferase 2
464024
Macaque
N-acetyltransferase 2 (arylamine N-acetyltransferase)
704357
Platypus
arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like
100077007
Zebrafish
ZDB-GENE-040801-107
445194
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acetyltransferase 2
Macaque
N-acetyltransferase 2 (arylamine N-acetyltransferase)
Platypus
arylamine N-acetyltransferase, pineal gland isozyme NAT-10-like
Zebrafish
Publication Statistics
PubMed Score 733.94
PubMed score by year
PubTator Score 1047.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title