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Tbio
RALB
Ras-related protein Ral-B

Protein Summary
Description
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (PubMed:17875936). In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269). This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided b ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272519
  • ENSP00000272519
  • ENSG00000144118
  • ENST00000420510
  • ENSP00000414224
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
interacting protein
0.94
disease perturbation
0.93
transcription factor perturbation
0.91
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.01   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.01   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
1
3
84.2
platelet count
1
1
1
56.2
intraocular pressure measurement
1
2
2
33.5
platelet crit
1
1
1
29.6
mathematical ability
3
1
3
20.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
84.2
platelet count
1
56.2
intraocular pressure measurement
2
33.5
platelet crit
1
29.6
mathematical ability
3
20.1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by NTRK1 (TRKA)
Reactome
Signaling by NTRKs
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signalling to ERKs
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by NTRK1 (TRKA)
Signaling by NTRKs
Signaling by Receptor Tyrosine Kinases
Signalling to ERKs
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (101)
1 – 10 of 101
TPP2
Tchem
Family: Enzyme
Novelty: 0.00803674
p_int: 0.999999992
p_ni: 8e-9
Score: 0.242
Data Source: BioPlex,STRINGDB
EXOC8
Tbio
Novelty: 0.03090842
p_int: 0.999970811
p_ni: 0.000029189
Score: 0.936
Data Source: BioPlex,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.999832699
p_ni: 0.000167301
Score: 0.927
Data Source: BioPlex,STRINGDB
PAM
Tchem
Family: Enzyme
Novelty: 0.00378397
p_int: 0.999069217
p_ni: 0.000930779
p_wrong: 4e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
ALDH18A1
Tbio
Family: Enzyme
Novelty: 0.00301673
p_int: 0.998420883
p_ni: 0.001579117
Score: 0.546
Data Source: BioPlex,STRINGDB
ANKRD13A
Tbio
Novelty: 0.61940334
p_int: 0.980876743
p_ni: 0.019123257
Data Source: BioPlex
DBT
Tbio
Family: Enzyme
Novelty: 0.0070589
p_int: 0.951677082
p_ni: 0.048322858
p_wrong: 6.1e-8
Score: 0.194
Data Source: BioPlex,STRINGDB
TGIF2LY
Tdark
Family: TF
p_int: 0.943630068
p_ni: 0.056369915
p_wrong: 1.8e-8
Data Source: BioPlex
XPO5
Tbio
Novelty: 0.0040002
p_int: 0.903314533
p_ni: 0.096685467
Score: 0.245
Data Source: BioPlex,STRINGDB
EXOC2
Tbio
Novelty: 0.01434464
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.01

PubMed score by year
PubTator Score  49.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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